Is local resection sufficient for parathyroid carcinoma?

Authors

  • Salim Ilksen Basceken Islahiye State Hospital; General Surgery
  • Volkan Genc Ankara University Medical School; Department of General Surgery
  • Siyar Ersoz Ankara Numune Training and Research Hospital; Department of General Surgery
  • Yusuf Sevim Ankara Penal Institution Campus State Hospital; General Surgery
  • Suleyman Utku Celik Ankara University Medical School; Department of General Surgery
  • Ilknur Kepenekci Bayram Ankara University Medical School; Department of General Surgery

DOI:

https://doi.org/10.6061/clinics/2015(04)05

Abstract

OBJECTIVES: Parathyroid carcinoma is a rare malignant disease of the parathyroid glands that appears in less than 1% of patients with primary hyperparathyroidism. In the literature, the generally recommended treatment is en bloc tumor excision with ipsilateral thyroid lobectomy. Based on our 12 years of experience, we discuss the necessity of performing thyroid lobectomy on parathyroid carcinoma patients. RESULTS: Eleven parathyroid carcinoma cases were included in the study. All operations were performed at the Department of Endocrine Surgery at Ankara University Medical School. Seven of the patients were male (63.6%), and the mean patient age was 48.9 ± 14.0 years. Hyperparathyroidism was the most common indication for surgery (n ϝ 10, 90.9%). Local disease was detected in 5 patients (45.5%), invasive disease was detected in 5 patients (45.5%) and metastatic disease was detected in 1 patient (9.1%). The mean follow-up period was 99.6 ± 42.1 months, and the patients' average disease-free survival was 96.0 ± 49.0 months. During the follow-up period, only 1 patient died of metastatic parathyroid carcinoma. CONCLUSION: Parathyroid carcinoma has a slow-growing natural progression, and regional lymph node metastases are uncommon. Although our study comprised few patients, it nevertheless showed that in selected cases, parathyroid carcinoma could be solely treated with parathyroidectomy.

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Published

2015-04-01

Issue

Section

Clinical Sciences

How to Cite

Is local resection sufficient for parathyroid carcinoma?. (2015). Clinics, 70(4), 247-249. https://doi.org/10.6061/clinics/2015(04)05