Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
AbstractOBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
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Paula, R. S., Souza, V. C., Machado-Silva, W., Almeida, B. R. S., Daros, A. C., Gomes, L., Ferreira, A. P., Brito, C. J., Córdova, C., Moraes, C. F., & Nóbrega, O. T. (2016). Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults . Clinics, 71(12), 725-732. https://doi.org/10.6061/clinics/2016(12)09