Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma


  • Omer Bilgehan Poyrazoglu General Surgery; Lokman Hekim Hospital
  • Ahmet Cumhur Dulger Yuzuncu Yil University; School of Medicine, Department of Gastroenterology
  • Bilge Sumbul Gultepe Bezmialem Vakif University; School of Medicine, Microbiology




Helicobacter pylori, Esophageal Squamous Cell Carcinoma, Turkey


OBJECTIVE: Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy. METHOD: The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively. RESULTS: The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>;0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively). CONCLUSION: These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.


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How to Cite

Poyrazoglu, O. B., Dulger, A. C., & Gultepe, B. S. (2017). Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma. Clinics, 72(3), 150-153. https://doi.org/10.6061/clinics/2017(03)04



Clinical Sciences