Human islet xenotransplantation in rodents: A literature review of experimental model trends

  • Leandro Ryuchi Iuamoto Universidade de São Paulo; Faculdade de Medicina
  • André Silva Franco Universidade de São Paulo; Faculdade de Medicina
  • Fábio Yuji Suguita Universidade de São Paulo; Faculdade de Medicina
  • Felipe Futema Essu Universidade de São Paulo; Faculdade de Medicina
  • Lucas Torres Oliveira Universidade de São Paulo; Faculdade de Medicina
  • Juliana Mika Kato Universidade de São Paulo; Faculdade de Medicina
  • Matheus Belloni Torsani Universidade de São Paulo; Faculdade de Medicina
  • Alberto Meyer Universidade de São Paulo; Departamento de Gastroenterologia, Faculdade de Medicina
  • Wellington Andraus Universidade de São Paulo; Departamento de Gastroenterologia, Faculdade de Medicina
  • Eleazar Chaib Universidade de São Paulo; Departamento de Gastroenterologia, Faculdade de Medicina
  • Luiz Augusto Carneiro D’Albuquerque Universidade de São Paulo; Departamento de Gastroenterologia, Faculdade de Medicina
Keywords: Islet Transplantation, Allograft, Transplantation, Heterologous, Islets of Langerhans

Abstract

Among the innovations for the treatment of type 1 diabetes, islet transplantation is a less invasive method of treatment, although it is still in development. One of the greatest barriers to this technique is the low number of pancreas donors and the low number of pancreases that are available for transplantation. Rodent models have been chosen in most studies of islet rejection and type 1 diabetes prevention to evaluate the quality and function of isolated human islets and to identify alternative solutions to the problem of islet scarcity. The purpose of this study is to conduct a review of islet xenotransplantation experiments from humans to rodents, to organize and analyze the parameters of these experiments, to describe trends in experimental modeling and to assess the viability of this procedure. In this study, we reviewed recently published research regarding islet xenotransplantation from humans to rodents, and we summarized the findings and organized the relevant data. The included studies were recent reports that involved xenotransplantation using human islets in a rodent model. We excluded the studies that related to isotransplantation, autotransplantation and allotransplantation. A total of 34 studies that related to xenotransplantation were selected for review based on their relevance and current data. Advances in the use of different graft sites may overcome autoimmunity and rejection after transplantation, which may solve the problem of the scarcity of islet donors in patients with type 1 diabetes.

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Published
2017-04-01
How to Cite
Iuamoto, L., Franco, A., Suguita, F., Essu, F., Oliveira, L., Kato, J., Torsani, M., Meyer, A., Andraus, W., Chaib, E., & D’Albuquerque, L. (2017). Human islet xenotransplantation in rodents: A literature review of experimental model trends. Clinics, 72(4), 238-243. https://doi.org/10.6061/clinics/2017(04)08
Section
Review