Burkholderia cepacia, cystic fibrosis and outcomes following lung transplantation: experiences from a single center in Brazil

Authors

  • Danila de Souza Carraro Universidade de São Paulo; Faculdade de Medicina; Hospital das Clinicas HCFMUSP
  • Rafael Medeiros Carraro Universidade de São Paulo; Faculdade de Medicina; Hospital das Clinicas HCFMUSP
  • Silvia Vidal Campos Universidade de São Paulo; Faculdade de Medicina; Hospital das Clinicas HCFMUSP
  • Leandro Ryuchi Iuamoto Universidade de São Paulo; Faculdade de Medicina; Hospital das Clinicas HCFMUSP
  • Karina Andrighetti de Oliveira Braga Universidade de São Paulo; Faculdade de Medicina FMUSP; Cardiopneumologia
  • Lea Campos de Oliveira Universidade de São Paulo; Faculdade de Medicina FMUSP; Laboratorio de Investigacao Medica (LIM3)
  • Ester Cerdeira Sabino Secretaria de Saúde do Estado de São Paulo; Fundacao Pro Sangue Hemocentro de Sao Paulo; Departamento de Biologia Molecular Divisao de Sorologia
  • Flavia Rossi Universidade de São Paulo; Faculdade de Medicina; Hospital das Clinicas HCFMUSP
  • Paulo Manuel Pêgo-Fernandes Universidade de São Paulo; Faculdade de Medicina FMUSP; Cardiopneumologia

DOI:

https://doi.org/10.6061/clinics/2018/e166

Keywords:

Lung Transplantation, Cystic Fibrosis, Burkholderia Cepacia Complex, Burkholderia cenocepacia, Prognosis

Abstract

OBJECTIVES: To evaluate the impact of Burkholderia cepacia complex colonization in cystic fibrosis patients undergoing lung transplantation. METHODS: We prospectively analyzed clinical data and respiratory tract samples (sputum and bronchoalveolar lavage) collected from suppurative lung disease patients between January 2008 and November 2013. We also subtyped different Burkholderia cepacia complex genotypes via DNA sequencing using primers against the recA gene in samples collected between January 2012 and November 2013. RESULTS: From 2008 to 2013, 34 lung transplants were performed on cystic fibrosis patients at our center. Burkholderia cepacia complex was detected in 13 of the 34 (38.2%) patients. Seven of the 13 (53%) strains were subjected to genotype analysis, from which three strains of B. metallica and four strains of B. cenocepacia were identified. The mortality rate was 1/13 (7.6%), and this death was not related to B. cepacia infection. CONCLUSION: The results of our study suggest that colonization by B. cepacia complex and even B. cenocepacia in patients with cystic fibrosis should not be considered an absolute contraindication to lung transplantation in Brazilian centers.

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Published

2018-01-01

How to Cite

de Souza Carraro, D., Carraro, R. M., Campos, S. V., Iuamoto, L. R., Braga, K. A. de O., Oliveira, L. C. de, Sabino, E. C., Rossi, F., & Pêgo-Fernandes, P. M. (2018). Burkholderia cepacia, cystic fibrosis and outcomes following lung transplantation: experiences from a single center in Brazil. Clinics, 73, e166. https://doi.org/10.6061/clinics/2018/e166

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Original Articles