Collagen I and III in women with diastasis recti

Authors

  • Rosa Maria Blotta Universidade Federal do Rio Grande do Sul; Cirurgia, Faculdade de Medicina
  • Sirlei dos Santos Costa Universidade Federal do Rio Grande do Sul; Cirurgia, Faculdade de Medicina
  • Eduardo Neubarth Trindade Universidade Federal do Rio Grande do Sul; Cirurgia, Faculdade de Medicina
  • Luise Meurer Hospital de Clinicas de Porto Alegre; Unidade de Patologia Experimental
  • Manoel Roberto Maciel-Trindade Hospital de Clinicas de Porto Alegre; Servico de Cirurgia Digestiva

DOI:

https://doi.org/10.6061/clinics/2018/e319

Keywords:

Abdomina Wall, Linea Alba, Diastasis Recti, Type I Collagen, Type III Collagen

Abstract

OBJECTIVES: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis recti is an increased width of the abdominal midline that is exclusively composed of interlacing aponeurotic expansions of the anterolateral abdominal muscles. The condition is common among women undergoing abdominoplasty, and many factors, not only mechanical, play a role. The goal of this study is to evaluate and compare collagen type I and III levels in the midline fascia of women with and without diastasis recti to report their possible influence on this condition. METHODS: This is a case-control study nested within a surgical cohort of 18 women with diastasis recti and 18 women without the condition (cases and controls, respectively). Fascia from the midline of the abdominal wall was collected and analyzed through immunohistochemistry using polyclonal antibodies to collagen type I and III. RESULTS: Both type I and type III collagen were less abundant in women with diastasis recti than in those without the condition, and the difference was statistically significant (p<0.001). CONCLUSION: Low collagen type I and type III levels in the midline of the abdominal wall may play a key role in the development of diastasis recti.

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Published

2018-01-01

Issue

Section

Original Articles

How to Cite

Blotta, R. M., Costa, S. dos S., Trindade, E. N., Meurer, L., & Maciel-Trindade, M. R. (2018). Collagen I and III in women with diastasis recti. Clinics, 73, e319. https://doi.org/10.6061/clinics/2018/e319