Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Authors

DOI:

https://doi.org/10.6061/clinics/2019/e739

Keywords:

Osteoporosis, Polymorphism, Vitamin K Epoxide Reductase Complex Subunit-1 Gene, Vertebral Fracture

Abstract

OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/ Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.

Downloads

Download data is not yet available.

Downloads

Published

2019-05-10

How to Cite

Ozgen, M., Cosan, D. T., Doganer, F., Soyocak, A., Armagan, O., Kuzgun, S., Aydogan, A. M., Gunes, H. V., Degirmenci, I., & Mutlu, F. (2019). Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study. Clinics, 74, e739. https://doi.org/10.6061/clinics/2019/e739

Issue

Section

Original Articles