Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis

Authors

  • Eduardo Carvalho de Arruda Veiga Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas https://orcid.org/0000-0002-0167-861X
  • Brunno Lemes de Melo Universidade Federal de Sao Paulo, Departamento de Medicina
  • Stella de Souza Vieira Universidade Federal de Sao Paulo, Departamento de Medicina
  • Ricardo S. Simões Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas
  • Vitor E. Valenti Universidade Estadual de Sao Paulo, Programa de PosGraduacao em Fisioterapia
  • Marcelo Ferraz Campos Centro Universitario Saude ABC
  • Joseane Elza Tonussi Mendez Rossetti do Vale Secretaria de Estado da Saude do Acre
  • Roberta Lukesvicius Rica Universidade Estacio de Sa, Departamento de Educacao Fisica
  • José Maria Soares-Júnior Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas https://orcid.org/0000-0003-0774-9404
  • Edmund Chada Baracat Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas https://orcid.org/0000-0003-0111-9030
  • Andrey Jorge Serra Universidade Federal de Sao Paulo, Departamento de Medicina
  • Julien S. Baker University of the West of Scotland, School of Health and Life Sciences, Institute for Clinical Exercise and Health Sciences
  • Danilo Sales Bocalini Universidade Federal do Espirito Santo, Centro de Educacao Fisica e Esporte, Laboratorio de Fisiologia e Bioquimica Experimental

DOI:

https://doi.org/10.6061/clinics/2020/e1293

Keywords:

Prior Exercise, Experimental Myocardial Infarctions, Systematic Reviews, Meta-Analysis, Exercise Training, Swimming, Running

Abstract

Exercising prior to experimental infarction may have beneficial effects on the heart. The objective of this study was to analyze studies on animals that had exercised prior to myocardial infarction and to examine any benefits through a systematic review and meta-analysis. The databases MEDLINE, Google Scholar, and Cochrane were consulted. We analyzed articles published between January 1978 and November 2018. From a total of 858 articles, 13 manuscripts were selected in this review. When animals exercised before experimental infarction, there was a reduction in mortality, a reduction in infarct size, improvements in cardiac function, and a better molecular balance between genes and proteins that exhibit cardiac protective effects. Analyzing heart weight/body weight, we observed the following results - Mean difference 95% CI - -0.02 [-0.61,0.57]. Metaanalysis of the infarct size (% of the left ventricle) revealed a statistically significant decrease in the size of the infarction in animals that exercised before myocardial infarction, in comparison with the sedentary animals -5.05 [-7.68, -2.40]. Analysis of the ejection fraction, measured by echo (%), revealed that animals that exercised before myocardial infarction exhibited higher and statistically significant measures, compared with sedentary animals 8.77 [3.87,13.66]. We conclude that exercise performed prior to experimental myocardial infarction confers cardiac benefits to animals.

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Published

2020-01-20

How to Cite

Veiga, E. C. de A., Melo, B. L. de, Vieira, S. de S., Simões, R. S., Valenti, V. E., Campos, M. F., Vale, J. E. T. M. R. do, Rica, R. L., Soares-Júnior, J. M., Baracat, E. C., Serra, A. J., Baker, J. S., & Bocalini, D. S. (2020). Prior exercise training and experimental myocardial infarction: A systematic review and meta-analysis. Clinics, 75, e1293. https://doi.org/10.6061/clinics/2020/e1293

Issue

Section

Review Articles