Association between bile acid metabolism and bone mineral density in postmenopausal women

Authors

  • Yu-Xiao Zhao Nanchang University Queen Mary School
  • Yu-Wen Song The Second Hospital of Shandong University
  • Liang Zhang The Second Hospital of Shandong University
  • Feng-Jie Zheng The Second Hospital of Shandong University
  • Xue-Meng Wang The Second Hospital of Shandong University
  • Xiang-Hua Zhuang The Second Hospital of Shandong University
  • Fei Wu The Second Hospital of Shandong University
  • Jian Liu The First Affiliated Hospital of Nanchang University https://orcid.org/0000-0002-0801-6811

DOI:

https://doi.org/10.6061/clinics/2020/e1486

Keywords:

Postmenopausal Osteoporosis, Bile Acid Metabolism, FGF19

Abstract

OBJECTIVES: Previous studies have not shown any correlation between bile acid metabolism and bone mineral density (BMD) in women with postmenopausal osteoporosis. Thus, the current study evaluated the association between bile acid levels as well as BMD and bone turnover marker levels in this group of women. METHODS: This single-center cross-sectional study included 150 postmenopausal Chinese women. According to BMD, the participants were divided into three groups: osteoporosis group, osteopenia group, and healthy control group. Serum bile acid, fibroblast growth factor 19 (FGF19), and bone turnover biomarker levels were assessed. Moreover, the concentrations of parathyroid hormone, 25-hydroxy vitamin D [25(OH)D], procollagen type I N-peptide (P1NP), and beta-CrossLaps of type I collagen containing cross-linked C-terminal telopeptide (bCTX) were evaluated. The BMD of the lumbar spine and proximal femur were examined via dual-energy X-ray absorptiometry. RESULTS: The serum total bile acid levels in the osteoporosis and osteopenia groups (5.28±1.56 and 5.31±1.56 umol/L, respectively) were significantly lower than that in the healthy control group (6.33±2.04 umol/L; p=0.002 and 0.018, respectively). Serum bile acid level was positively associated with the BMD of the lumbar spine, femoral neck, and total hip. However, it negatively correlated with b-CTX concentration. Moreover, no correlation was observed between bile acid and P1NP levels, and the levels of the other biomarkers that were measured did not differ between the groups. CONCLUSION: Serum bile acid was positively correlated with BMD and negatively correlated with bone turnover biomarkers reflecting bone absorption in postmenopausal women. Thus, bile acid may play an important role in bone metabolism.

Downloads

Download data is not yet available.

Downloads

Published

2020-03-30

How to Cite

Zhao, Y.-X., Song, Y.-W., Zhang, L., Zheng, F.-J., Wang, X.-M., Zhuang, X.-H., Wu, F., & Liu, J. (2020). Association between bile acid metabolism and bone mineral density in postmenopausal women. Clinics, 75, e1486. https://doi.org/10.6061/clinics/2020/e1486

Issue

Section

Original Articles