microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma

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DOI:

https://doi.org/10.6061/clinics/2020/e1804

Keywords:

Retinoblastoma, miR-144, Diagnosis, Prognosis

Abstract

OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.

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Published

2020-08-27

How to Cite

Zheng, Q., Zhu, Q., Li, C., Hao, S., Li, J., Yu, X., Qi, D., & Pan, Y. (2020). microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma. Clinics, 75, e1804. https://doi.org/10.6061/clinics/2020/e1804

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Section

Original Articles