Diacerhein versus glucosamine in a rat model of osteoarthritis
DOI:
https://doi.org/10.1590/S1807-59322006000500014Keywords:
Rats, Knee, Osteoarthritis, Anthraquinone, Meniscectomy, GlucosamineAbstract
PURPOSE: The purpose of this study was to compare the chondroprotective effect of diacerein and glucosamine regarding degenerative changes and articular stiffness in an experimental model of arthritis. METHODS: Twenty rats underwent medial meniscectomy on the right knee. Ten animals were given diacerhein, and 10 were given glucosamine, from day 1 to the third month postoperatively, when all of them were killed. Histological and functional analysis of the knees were performed (measurement of maximum extension). RESULTS: All operated knees showed more limited extension values and more degenerative changes as compared to nonoperated contralateral sides. A comparison of the two drugs showed that the degree of articular stiffness was significantly lower with diacerein, although degenerative changes were similar. CONCLUSIONS: 1) Prophylactic use of diacerein leads to lower degree of articular stiffness when compared to glucosamine; 2) The prophylactic chondroprotective effects of diacerein and glucosamine are histologically similar.Downloads
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Published
2006-10-01
Issue
Section
Basic Research
How to Cite
Diacerhein versus glucosamine in a rat model of osteoarthritis . (2006). Clinics, 61(5), 461-466. https://doi.org/10.1590/S1807-59322006000500014