Glucocorticoid-induced osteoporosis in rheumatic diseases
DOI:
https://doi.org/10.1590/S1807-59322010001100024Keywords:
Osteoporosis, Glucocorticoids, Bone mineral density, Fractures, Rheumatic diseasesAbstract
The aim of this article is to review rheumatological diseases that are associated with glucocorticoid-induced osteoporosis or fractures and to perform a critical analysis of the current guidelines and treatment regimens. The electronic database MEDLINE was searched using the date range of July 1986 to June 2009 and the following search terms: osteoporosis, bone mineral density, fractures, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, vasculitis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis and juvenile dermatomyositis. Osteopenia and osteoporosis respectively account for 1.4 to 68.7% and 5.0 to 61.9% of adult rheumatological diseases. Among juvenile rheumatological disorders, the frequency of low bone mass ranges from 38.7 to 70%. In general, fracture rates vary from 0 to 25%. Although glucocorticoid-induced osteoporosis has a high rate of prevalence among rheumatic diseases, a relatively low number of patients on continuous glucocorticoid treatment receive adequate diagnostic evaluation or preventive therapy. This deficit in patient care may result from a lack of clear understanding of the attributed risks by the patients and physicians, the high complexity of the treatment guidelines and poor patient compliance.Downloads
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Published
2010-01-01
Issue
Section
Review
How to Cite
Glucocorticoid-induced osteoporosis in rheumatic diseases . (2010). Clinics, 65(11), 1197-1205. https://doi.org/10.1590/S1807-59322010001100024