Overexpression of serum extracellular vesicle microRNA-215-5p is associated with early tumor recurrence and poor prognosis of gastric cancêr

Authors

  • Yunfei Zhang The First Affiliated Hospital of Kunming Medical University. Department of Oncology
  • Fengchang Huang The First Affiliated Hospital of Kunming Medical University. Department of Oncology
  • Ning Xu The First Affiliated Hospital of Kunming Medical University. Department of Oncology
  • Jin Wang The First Affiliated Hospital of Kunming Medical University. Department of Vascular Surgery
  • Dan Li Yunnan Hospital of Integrated Traditional Chinese and Western Medicine. Department of Acupuncture
  • Liang Yin The First Affiliated Hospital of Kunming Medical University. Department of Oncology

DOI:

https://doi.org/10.6061/clinics/2021/e2081

Keywords:

Gastric Cancer, Serum Extracellular Vesicle miR-215-5p, Early Tumor Recurrence, Prognosis, Diagnosis

Abstract

OBJECTIVES: Extracellular vesicle microRNAs (EV-miRNAs) have been demonstrated to be reliable candidate biomarkers for clinical applications. However, the clinical application potential of serum EV-miR-215-5p for gastric cancer (GC) remains poorly understood. The goal of our study was to determine the efficacy of serum EV-miR-215-5p in predicting the prognosis of GC. METHODS: Blood samples were collected from 118 patients with GC, 60 patients with benign gastric disease and BGD and 70 healthy controls. The relative levels of serum EV-miR-215-5p were measured using quantitative realtime polymerase chain reaction (qRT-PCR). RESULTS: Compared to patients with BGD and normal controls, GC patients exhibited remarkably higher serum EV-miR-215-5p level, especially those with early tumor recurrence (ETR). Receiver operating characteristic (ROC) curve analysis showed that serum EV-miR-215-5p was able to distinguish GC patients from BGD patients or healthy controls and GC patients with ETR from those without ETR. In addition, increased serum EV-miR-215-5p levels were notably correlated with invasive depth, TNM stage, and lymph node metastasis. Moreover, serum EV-miR-215-5p levels were greatly decreased after surgical treatment, but increased at the time of ETR. Survival analysis showed that patients with higher serum EV-miR-215-5p had shorter survival. Furthermore, serum EV-miR-215-5p was an independent risk factor for GC. CONCLUSIONS: Serum EV-miR-215-5p might be a novel biomarker for predicting ETR and prognosis of GC.

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Published

2021-11-09

Issue

Section

Original Articles

How to Cite

Overexpression of serum extracellular vesicle microRNA-215-5p is associated with early tumor recurrence and poor prognosis of gastric cancêr. (2021). Clinics, 76, e2081. https://doi.org/10.6061/clinics/2021/e2081