Geriatric nutritional risk index predicts all-cause mortality in patients with heart failure: A systematic review and meta-analysis

Authors

  • Chao-hui Dong Affiliated Hospital of Chengdu University. Department of Health Management Center
  • Si-yu Chen Sichuan Academy of Medical Sciences. Department of Vascular Surgery
  • Hong-lian Zeng Affiliated Hospital of Chengdu University. Department of Health Management Center
  • Bo Yang Affiliated Hospital of Chengdu University. Department of Health Management Center
  • Jia Pan Affiliated Hospital of Chengdu University. Department of Health Management Center

DOI:

https://doi.org/10.6061/clinics/2021/e2258

Keywords:

Geriatric Nutritional Risk Index, Heart Failure, All-Cause Mortality

Abstract

OBJECTIVES: Geriatric nutritional risk index (GNRI) might predict the all-cause mortality in patients with heart failure (HF). We performed a meta-analysis to evaluate the correlation between GNRI and all-cause mortality in patients with HF. METHODS: We searched the PubMed, Medline, Cochrane Library, and Embase databases for clinical trials investigating the association between GNRI and all-cause mortality in patients with HF, having the primary endpoint as all-cause mortality. RESULTS: In total, nine studies involving 7,659 subjects were included in the systematic review and metaanalysis. The results indicated that major risk and moderate risk GNRI (GNRIo92) was associated with an increased risk of all-cause mortality in elderly patients with HF (hazard ratios [HR] 1.59, 95% confidence intervals [CI] 1.37-1.85). Low risk GNRI (GNRIo98) group predicted all-cause mortality in elderly HF patients (HR 1.56, 95%CI 1.12-2.18) when compared with the high GNRI value group. A subgroup analysis indicated that the relationship between GNRI and HF might differ based on the subtype of heart failure. CONCLUSIONS: GNRI is a simple and well-established nutritional assessment tool to predict all-cause mortality in patients with HF.

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Published

2021-11-09

Issue

Section

Review Articles

How to Cite

Geriatric nutritional risk index predicts all-cause mortality in patients with heart failure: A systematic review and meta-analysis. (2021). Clinics, 76, e2258. https://doi.org/10.6061/clinics/2021/e2258