Oral manifestation of multiple myeloma: a case report



Oral Diagnosis, Multiple Myeloma, Oral Cancer


Multiple myeloma (MM) is a relatively uncommon oncohematological condition characterized by abnormal proliferation of plasma cells. Oral manifestations of MM can occur in soft and intraosseous parts. We present a case of a 69-year-old man diagnosed with MM and undergoing chemotherapy, referred to the dental service complaining of a nodular swelling in the maxilla. An incisional biopsy was conducted and the histopathological analysis showed a monoclonal proliferation of plasma cells with a positive CD 138 immunophenotype, which allowed the diagnosis of extramedullary plasmacytoma. The outcome of the case was unfavorable and the patient died. We emphasize the importance of diagnosing MM extramedullary disease in the maxillofacial region.


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Author Biographies

Jefferson da Rocha Tenório, Universidade de São Paulo

Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil; Faculdade de Odontologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

Basílio de Almeida Milani, Hospital Municipal do Campo Limpo

Hospital Municipal do Campo Limpo, São Paulo, SP. Brazil

Bruno Fernandes Matuck, Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil


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