Evaluation between vitamin D serum level and Herpes Simplex Virus Type 1 in the field of dentistry


  • Parvin Parvaie Birjand University of Medical Sciences
  • Saideh Ebrahimian Baghan Birjand University of Medical Sciences
  • Freshteh Osmani Birjand University of Medical Sciences




Herpesvirus, Vitamin D Deficiency, Dentistry


Objectives: Our study sought to evaluate the association between HSV1 and serum 25-hydroxyvitamin D (25(OH) D) levels among dental students. Materials & Methods: This is a cross-sectional study with a quantitative approach conducted in Birjand, state of Khorasan Jonoobi, Iran, from July 2018 to April 2019. A peripheral blood sample (5 ml) and an anti-virus antibody along with Serum 25-hydroxyvitamin D (1,25(OH)2D3) levels were measured using an Anti-Herpes-1 IgG kit with ELISA by a pathologist. Pearson and chi-square tests were applied in the significance level of 5%. Results: The prevalence of HSV1 was 41%. The serum 25-hydroxyvitamin D3 levels mean was 23.22 ± 13.09. The prevalence of HSV1 antibody in pre-clinical and clinical levels was higher than in basic science, also, the results represented that a negative relation between vitamin D deficiency and the presence of HSV1, but it was not a significant association. Conclusion: Any association between vitamin D and herpes viruses remains inconclusive. Further studies in the general population are needed.


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Author Biographies

  • Parvin Parvaie, Birjand University of Medical Sciences

    Department of Oral and Maxollofacial Medicine, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran

  • Saideh Ebrahimian Baghan, Birjand University of Medical Sciences

    Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

  • Freshteh Osmani, Birjand University of Medical Sciences

    Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran


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Original Research

How to Cite

Parvaie, P., Baghan, S. E. ., & Osmani, F. (2021). Evaluation between vitamin D serum level and Herpes Simplex Virus Type 1 in the field of dentistry. Clinical and Laboratorial Research in Dentistry. https://doi.org/10.11606/issn.2357-8041.clrd.2021.182206