Evaluation between vitamin D serum level and Herpes Simplex Virus Type 1 in the field of dentistry
Keywords:Herpesvirus, Vitamin D Deficiency, Dentistry
Objectives: Our study sought to evaluate the association between HSV1 and serum 25-hydroxyvitamin D (25(OH) D) levels among dental students. Materials & Methods: This is a cross-sectional study with a quantitative approach conducted in Birjand, state of Khorasan Jonoobi, Iran, from July 2018 to April 2019. A peripheral blood sample (5 ml) and an anti-virus antibody along with Serum 25-hydroxyvitamin D (1,25(OH)2D3) levels were measured using an Anti-Herpes-1 IgG kit with ELISA by a pathologist. Pearson and chi-square tests were applied in the significance level of 5%. Results: The prevalence of HSV1 was 41%. The serum 25-hydroxyvitamin D3 levels mean was 23.22 ± 13.09. The prevalence of HSV1 antibody in pre-clinical and clinical levels was higher than in basic science, also, the results represented that a negative relation between vitamin D deficiency and the presence of HSV1, but it was not a significant association. Conclusion: Any association between vitamin D and herpes viruses remains inconclusive. Further studies in the general population are needed.
Chiang KC, Yeh CN, Chen MF, Chen TC. Hepatocellular carcinoma and vitamin D: a review. J Gastroenterol Hepatol. 2011;26(11):1597-603. Doi: https://doi.org/10.1111/j.1440-1746.2011.06892.x
Osmani F. Effect evaluation of vitamin D level amongst patients with chronic hepatitis B. Arch Pathol Clin Res. 2019;3:20-1. Doi: https://doi.org/10.29328/journal.apcr.1001014
Osmani F, Ziaee M. Assessment of the risk factors for vitamin D3 deﬁciency in chronic hepatitis B patient using the decision tree learning algorithm in birjand. Inform Med Unlocked. 2021;23:100519. Doi: https://doi.org/10.1016/j.imu.2021.100519
Osmani F, Hajizadeh E, Rasekhi A, Akbari ME. Prognostic factors associated with locoronal relapses, metastatic relapses, and death among women with breast cancer. Population-based cohort study. Breast. 2019;48:82-8. Doi: https://doi.org/10.1016/j.breast.2019.09.010
Fujii H, Nakai K, Yonekura Y, Kono K, Goto S, Hirata M, et al. The vitamin D receptor activator maxacalcitol provides cardioprotective effects in diabetes mellitus. Cardiovasc Drugs Ther. 2015;29(6):499-507. Doi: https://doi.org/10.1007/s10557-015-6629-y
Ghaziasadi A, Ziaee M, Norouzi M, Malekzadeh R, Alavian SM, Saberfar E, et al. The prevalence of hepatitis B virus surface antigen (HBsAg) variations and correlation with the clinical and serologic pictures in chronic carriers from Khorasan Province, North-East of Iran. Acta Med Iran. 2012;50(4):265-72.
Heshmat R, Mohammad K, Majdzadeh S, Forouzanfar M, Bahrami A, Ranjbar Omrani G, et al. Vitamin D deficiency in Iran: A multi-center study among different urban areas. Iran J Public Health. 2008;37(1):72-8.
Osmani M, Osmani F, Pourhoseingholi MA. Comparison of Decision Tree and Logistic Regression for Prediction of Functional Dyspepsia and Gastroesophageal Reflux Disease in Tehran Province Using Rome III. Mod Care J. 2019;16(4):e94669. Doi: https://doi.org/10.5812/modernc.94669
Parvaie P, Majd HS, Ziaee M, Sharifzadeh G, Osmani F. Evaluation of gum health status in hemophilia patients in Birjand (a case-control study). Am J Blood Res. 2020;10(3):54-9.
Azarkar G, Doosti Z, Osmani F, Ziaee M. Analysis Of Risk Factors For Nonalcoholic Fatty-Liver Disease In Hepatitis B Virus Infection: A Case-Control Study. Hepat Med. 2019;11:153-8.
Hoan NX, Khuyen N, Binh MT, Giang DP, Van Tong H, Hoan PQ, et al. Association of vitamin D deficiency with hepatitis B virus-related liver diseases. BMC Infect Dis. 2016;16(1):507. Doi: https://doi.org/10.1186/s12879-016-1836-0
Rezaei-Chaparpordi S,Assmar M, Amirmozafari N, Modiri L, Massiha A, Gholizadeh Z. Seroepidemiology of Herpes Simplex Virus Type 1 and 2 in Anzali city 2010-2011. Zahedan J Res Med Sci. 2012;14(8):67-9.
Androutsakos T, Sipsas N, Kontos A, Hatzis G. HCV treatment in HIV/HCV co-infected patients A single center, observational study. Arch Hell Med. 2019;36(6):787-91.
Osmani F, Azarkar G. Fitting logistic regression models to assess vitamin D deficiency with clinical parameters in chronic hepatitis B patients. Infect Dis Model. 2021;6:612-7. Doi: https://doi.org/10.1016/j.idm.2021.03.008
Hu YC, Wang WW, Jiang WY, Li CQ, Guo JC, Xun YH. Low vitamin D levels are associated with high viral loadas in patients with chronic hepatitis B: A systematic review and meta-analysis. BMC Gastroenterol. 2019;19(1):84.
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