Epigenetic correlations of oral cancer and periodontal disease

Authors

  • Amanda Hastenreiter Costa Dornelas Universidade Federal de Juiz de Fora
  • Karla de Andrade Luiz Universidade Federal de Juiz de Fora
  • Victória Boechat Feyo Universidade Federal de Juiz de Fora
  • Yuri de Lima Medeiros Universidade Federal de Juiz de Fora
  • Ana Carolina Alves Pereira Universidade Federal de Juiz de Fora
  • Raissa Caputo de Azevedo Universidade Federal de Juiz de Fora
  • Gisele Maria Campos Fabri Universidade Federal de Juiz de Fora

DOI:

https://doi.org/10.11606/issn.2357-8041.clrd.2021.187977

Keywords:

Periodontal disease, Oral squamous cells carcinoma, Cancer, Epigenetics, Methylation, Histone

Abstract

This study aimed to understand the association between epigenetic alterations in cancer and periodontal disease, verifying a potential biological plausibility. To this end, a narrative literature review was conducted in the LILACS, PubMed and SciELO databases for the descriptors “Epigenetic AND Periodontal disease,” “Epigenetic AND Oral cancer,” and “Epigenetic AND Periodontal disease AND Oral cancer”. The search returned 56 articles. Scientific evidence shows that chronic inflammation resulting from the presence of periodontopathogenic bacteria in the dental biofilm can lead to epigenetic modifications such as DNA methylation and histone. These changes can inhibit tumor suppressor genes and activate oncogenes, contributing to the development and progression of oral cancer. This indicates that epigenetic modifications in cancer and periodontal disease present similar pathophysiological mechanisms, thus pointing to a positive association between these two diseases and suggesting that periodontal disease may be a potential risk factor for oral cancer.

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Author Biographies

  • Amanda Hastenreiter Costa Dornelas , Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Karla de Andrade Luiz, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Victória Boechat Feyo, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Yuri de Lima Medeiros, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Ana Carolina Alves Pereira, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Raissa Caputo de Azevedo, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

  • Gisele Maria Campos Fabri, Universidade Federal de Juiz de Fora

    Faculdade de Odontologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil

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Published

2021-11-10

Issue

2021

Section

Literature review

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Copyright (c) 2021 Amanda Hastenreiter Costa Dornelas , Karla de Andrade Luiz, Victória Boechat Feyo, Yuri de Lima Medeiros, Ana Carolina Alves Pereira, Raissa Caputo de Azevedo, Gisele Maria Campos Fabri

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