Local recurrences of salivary gland tumors in a Brazilian population


  • Maria Eduarda de Arruda Lucena Universidade de Pernambuco
  • Hittalo Carlos Rodrigues de Almeida Universidade de Pernambuco
  • Leorik Pereira da Silva Universidade Federal de Campina Grande
  • Márcia Maria Fonseca da Silveira Universidade de Pernambuco
  • Ana Paula Veras Sobral Universidade de Pernambuco




Salivary gland neoplasms, Neoplasm metastasis, Prognosis


Objective: To identify the recurrence after surgery in patients diagnosed with salivary gland tumor. Methods: Data on age, gender, type of salivary gland tumor, local recurrence, stage, primary site and type of treatment were collected at Hospital de Câncer de Pernambuco, Recife, Brazil, using a standard form based on clinical records. These were described and analyzed with a significance level of 5% (p < 0.05). Results: Of the 55 medical records that comprised the study sample, 51% were male. Overall mean age was 55 years, ranging from 13 to 90 years. Adenocarcinoma (NOS) was the most prevalent (n = 17), followed by adenoid cystic carcinoma (ACC) (n = 14; 25.5%). Among all sites, parotid gland (n = 29; 53%) was the most common. Among the patients studied, 61.8% (n = 34) had no distant metastasis, but 38.18% (n = 21) did, and 14.55% (n = 8) showed bone metastasis. Conversely, 34.55% (n = 19) of the patients had recurrence only one year after diagnosis. The neoplasm with the highest recurrence rate was NOS (n = 17, 30.91%), followed by CAC (n = 14, 25.45%). Conclusion: Results show a prevalence of male patients and parotid gland involvement, with NOS adenocarcinoma and CAC being the most frequent neoplasms. Distant metastasis occurred in 38.18% (n = 21) of the cases, and bone was the most affected site. Surgery with adjuvant radiotherapy (n = 15) was the treatment of choice.


Download data is not yet available.

Author Biographies

Maria Eduarda de Arruda Lucena, Universidade de Pernambuco

Faculdade de Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.

Hittalo Carlos Rodrigues de Almeida, Universidade de Pernambuco

Faculdade de Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.

Leorik Pereira da Silva, Universidade Federal de Campina Grande

Faculdade de Odontologia, Universidade Federal de Campina Grande – Campus Patos, Paraíba, PB, Brasil.

Márcia Maria Fonseca da Silveira, Universidade de Pernambuco

Faculdade de Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.

Ana Paula Veras Sobral, Universidade de Pernambuco

Faculdade de Odontologia, Universidade de Pernambuco, Recife, PE, Brasil.


Carlson ER, Schlieve T. Salivary gland malignancies. Oral Maxillofac Surg Clin North Am. 2019;31(1):125-44. Doi: https://doi.org/10.1016/j.coms.2018.08.007.

Shen SY, Wang WH, Liang R, Pan GQ, Qian YM. Clinicopathologic analysis of 2736 salivary gland cases over a 11-year period in Southwest China. Acta Otolaryngol. 2018;138(8):746-9. Doi: https://doi.org/10.1080/00016489.2018.1455108.

Santana BW, Silva LP, Serpa MS, Borges MD, Moura SR, Silveira MM, et al. Incidence and profile of benign epithelial tumors of salivary glands from a single center in Northeast of Brazil. Med Oral Patol Oral Cir Bucal. 2021;26(1):e108-13. Doi: https://doi.org/10.4317/medoral.24056.

Gao M, Hao Y, Huang MX, Ma DQ, Chen Y, Luo HY, et al. Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases. Int J Oral Maxillofac Surg. 2017;46(3):343-9. Doi: https://doi.org/10.1016/j.ijom.2016.09.021.

Fonseca FP, Carvalho MV, Almeida OP, Rangel AL, Takizawa MC, Bueno AG, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(2):230-9. Doi: https://doi.org/10.1016/j.oooo.2012.04.008.

Slootweg PJ, El-Naggar AK. World Health Organization 4th edition of head and neck tumor classification: insight into the consequential modifications. Virchows Arch. 2018;472(3):311-3. Doi: https://doi.org/10.1007/s00428-018-2320-6.

Wang X, Luo Y, Li M, Yan H, Sun M, Fan T. Management of salivary gland carcinomas – a review. Oncotarget. 2017;8(3):3946-56. Doi: https://doi.org/10.18632%2Foncotarget.13952.

Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8(3):177-84. Doi: https://doi.org/10.1002/hed.2890080309.

Pinheiro J, Sá Fernandes M, Pereira AR, Lopes JM. Histological subtypes and clinical behavior evaluation of salivary gland tumors. Acta Med Port. 2018;31(11):641-7. Doi: https://doi.org/10.20344/amp.9023.

Bittar RF, Ferraro HP, Moraes Gonçalves FT, Couto da Cunha MG, Biamino ER. Neoplasms of the salivary glands: analysis of 727 histopathological reports in a single institution. Otolaryngol Pol. 2015;69(4):28-33. Doi: https://doi.org/10.5604/00306657.1163578.

da Silva LP, Serpa MS, Viveiros SK, Sena DA, de Carvalho Pinho RF, de Abreu Guimarães LD, et al. Salivary gland tumors in a Brazilian population: a 20-year retrospective and multicentric study of 2292 cases. J Craniomaxillofac Surg. 2018;46(12):2227-33. Doi: https://doi.org/10.1016/j.jcms.2018.09.028.

Campolo González A, Ramírez Skinner H, Vargas Díaz A, León Ramírez A, Goñi Espildora I, Solar González A. Perfil epidemiológico de neoplasias epiteliales de glándulas salivales. Rev Med Chil. 2018;146(10):1159-66. Doi: http://dx.doi.org/10.4067/S0034-98872018001001159.

Wang XD, Meng LJ, Hou TT, Huang SH. Tumours of the salivary glands in northeastern China: a retrospective study of 2508 patients. Br J Oral Maxillofac Surg. 2015;53(2):132-7. Doi: https://doi.org/10.1016/j.bjoms.2014.10.008.

Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg. 2010;39(3):235-42. Doi: https://doi.org/10.1016/j.ijom.2009.10.016.

Sarmento DJ, Morais ML, Costa AL, Silveira EJ. Minor intraoral salivary gland tumors: a clinical-pathological study. Einstein (Sao Paulo). 2016;14(4):508-12. Doi: https://doi.org/10.1590/S1679-45082016AO3749.

Iqbal N, Iqbal N. Imatinib: a breakthrough of targeted therapy in cancer. Chemother Res Pract. 2014;2014:357027. Doi: https://doi.org/10.1155/2014/357027.

Vasconcelos AC, Nör F, Meurer L, Salvadori G, Souza LB, Vargas PA, et al. Clinicopathological analysis of salivary gland tumors over a 15-year period. Braz Oral Res. 2016;30:S1806-83242016000100208. Doi: https://doi.org/10.1590/1807-3107BOR-2016.vol30.0002.

Abrahão AC, Santos Netto JN, Pires FR, Santos TC, Cabral MG. Clinicopathological characteristics of tumours of the intraoral minor salivary glands in 170 Brazilian patients. Br J Oral Maxillofac Surg. 2016;54(1):30-4. Doi: https://doi.org/10.1016/j.bjoms.2015.10.035.

Li TI, Chiang MT, Chiu KC, Lai CH, Liu SY, Shieh YS. The association of betel quid, alcohol, and cigarettes with salivary gland tumor-A case-control study. J Dent Sci. 2017;12(2):151-5. Doi: https://doi.org/10.1016/j.jds.2016.12.002.

Szewczyk M, Golusiński P, Pazdrowski J, Pieńkowski P, Marszałek S, Sygut J, et al. Patterns of treatment failure in salivary gland cancers. Rep Pract Oncol Radiother. 2018;23(4):260-5. Doi: https://dx.doi.org/10.1016%2Fj.rpor.2018.05.004.

Pacheco-Ojeda L, Domeisen H, Narvaez M, Tixi R, Vivar N. Malignant salivary gland tumors in Quito, Ecuador. ORL J Otorhinolaryngol Relat Spec. 2000;62(6):296-302. Doi: https://doi.org/10.1159/000027772.

Rajappa SK, Bhakuni YS, Ram D, Shukla H, Ranjan R, Dewan A, et al. A gland of diverse pathology and unpredictable behaviour: our experience of primary submandibular gland malignancies. Int J Oral Maxillofac Surg. 2018;47(10):1243-9. Doi: https://doi.org/10.1016/j.ijom.2018.05.012.





Original Research