A systematic review of the long-term effects of dental development disturbances after hematopoietic stem-cell transplantation in pediatric patients


  • Alexandre Viana Frascino Department of Oral Surgery, Faculdades Metropolitanas Unidas, São Paulo, SP
  • Fábio Luiz Coracin Oral Pathology and Medicine, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, SP
  • Paulo Sérgio da Silva Santos Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP




Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantation, Child, Drug Therapy, Radiotherapy.


The purpose of this systematic review was to evaluate published data and to update our current knowledge about the impact on dental development of childhood hematopoietic stem-cell transplantation (HSCT), as well as the late effects of preparative regimens, for the treatment of onco-hematological malignancies. A systematic literature research was conducted to assess articles published since January 1980 until the present day that fi tted the predetermined inclusion/exclusion criteria. Data compilation was divided into qualitative and quantitative dental development disturbances. Demographic records were also gathered. First and second premolars and second molars were signifi cantly more affected in HSCT children. There was a positive correlation between age at the time of anticancer therapy administration and qualitative and quantitative dental development disturbances. The association of total body or head and neck radiation mieloablative treatments was shown to enhance the magnitude of dental development disturbances. Dental development disturbances due to childhood HSCT are commonly seen in long-term survivors. The knowledge of these alterations may help improve dental care and elevate the quality of life of these patients. Further studies are needed to understand the long-term effects of dental development disturbances in this group of patients.


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Author Biographies

Fábio Luiz Coracin, Oral Pathology and Medicine, Clinics Hospital, School of Medicine, University of São Paulo, São Paulo, SP

DMD, PhD, Oral Pathology and Medicine, Hematopoietic Stem Cell Transplantation, Clinics Hospital School of Medicine - University of São Paulo, São Paulo, Brazil. Nove de Julho University, Department of Health, São Paulo, SP, Brazil

Paulo Sérgio da Silva Santos, Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, SP

DDS, MD, PhD, Department of Stomatology, Bauru School of Dentistry - University of São Paulo, São Paulo, Brazil


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Systematic Review