Fotobiomodulação Laser na resposta inflamatória aguda em lesão do tendão calcâneo em ratos expostos a fumaça de cigarro
DOI:
https://doi.org/10.1590/1809-2950/18032726022019Palavras-chave:
Terapia a Laser de Baixa Intensidade, Tendão do Calcâneo, Tendinopatia, InflamaçãoResumo
A nicotina retarda o processo de cicatrização e eleva os níveis da enzima mieloperoxidase (MPO), a qual possui um papel fundamental na produção de espécies reativas de oxigênio durante o processo inflamatório. A fotobiomodulação laser (FBM) é um dos agentes eletrofísicos mais utilizados no tratamento do tendão calcâneo, no entanto, os seus efeitos sobre a atividade da MPO carecem de maior elucidação. Este estudo objetivou avaliar os efeitos da FBM sobre a atividade da MPO, após lesão do tendão calcâneo em ratos expostos à fumaça de cigarro. Foram utilizados 34 ratos Wistar, machos, com 90 dias de vida. Após 14 dias de exposição à fumaça de cigarro, os animais foram divididos em três grupos experimentais: grupo controle (GC, n=12), não submetido à lesão ou tratamento; grupo sham (GSh, n=10), submetido à lesão parcial do tendão calcâneo e a simulação da FBM laser; grupo FBM laser (GFBM, n=12), submetido à lesão parcial do tendão calcâneo e tratados com FBM laser, no primeiro minuto após a lesão. A FBM diminuiu os níveis de atividade da MPO no GFBM em comparação ao GSh (GC: 1,38±0,69 pg/ml; GSh: 3,78±1,09pg/ml; GFBM: 2,58±0,93pg/ml; p<0,005). Conclui-se que a FBM laser aplicada imediatamente após lesão do tendão calcâneo, atenua a atividade inflamatória aguda em ratos expostos à fumaça de cigarro.
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Copyright (c) 2019 Naira Helena Bohrer Scherer, Antonio Marcos Vargas da Silva, Jessié Gutierres, Carolina Fantinel Veloso, Carlos Eduardo Pinfildi, Rafael Corrêa Gobbato
Este trabalho está licenciado sob uma licença Creative Commons Attribution-ShareAlike 4.0 International License.
