Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Authors

  • Young Sun HWANG Eulji University; College of Health Science; Department of Dental Hygiene
  • Sang-Sun HAN Eulji University; College of Health Science; Department of Dental Hygiene
  • Ki-Rim KIM Kyungpook National University; Department of Dental Hygiene
  • LEE Ye-Jin Eulji University; College of Health Science; Department of Dental Hygiene
  • LEE Sun-Kyung Yonsei University
  • PARK Kwang-Kyun Yonsei University
  • CHUNG Won-Yoon Yonsei University

DOI:

https://doi.org/10.1590/1678-775720140158

Abstract

Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.

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Published

2015-02-01

Issue

Section

Original Articles

How to Cite

Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible . (2015). Journal of Applied Oral Science, 23(1), 3-8. https://doi.org/10.1590/1678-775720140158