Effect of 1% sodium alendronate in the non-surgical treatment of periodontal intraosseous defects: a 6-month clinical trial

Authors

  • Bernardo Carvalho DUTRA Universidade Federal de Minas Gerais; Faculdade de Odontologia; Departamento de Patologia e Cirurgia
  • Alcione Maria Soares Dutra OLIVEIRA Pontífica Universidade Católica of Minas Gerais; Departamento de Periodontia
  • Peterson Antônio Dutra OLIVEIRA Pontífica Universidade Católica of Minas Gerais; Departamento de Periodontia
  • Flavio Ricardo MANZI Pontífica Universidade Católica of Minas Gerais; Departamento de Periodontia
  • Sheila Cavalca CORTELLI Universidade de Taubaté; Departamento de Odontologia; Divisão de Pesquisa Periodontal
  • Luís Otávio de Miranda COTA Universidade Federal de Minas Gerais; Faculdade de Odontologia; Departamento de Patologia e Cirurgia
  • Fernando Oliveira COSTA Universidade Federal de Minas Gerais; Faculdade de Odontologia; Departamento de Patologia e Cirurgia

DOI:

https://doi.org/10.1590/1678-7757-2016-0252

Keywords:

Sodium, alendronate, Biphosphonates, Periodontitis, Dental scaling

Abstract

Background and objectives Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT). Material and Methods Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05). Results Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment. Conclusions Topical application of 1% ALN might be a beneficial adjuvant to non-surgical periodontal therapy.

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Published

2017-06-01

Issue

Section

Original Articles