Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Authors

  • Cintia Kazuko Tokuhara Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Bauru, São Paulo http://orcid.org/0000-0002-1852-5986
  • Mariana Rodrigues Santesso Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Bauru, São Paulo http://orcid.org/0000-0001-9740-1780
  • Gabriela Silva Neubern de Oliveira Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Bauru, São Paulo http://orcid.org/0000-0003-0037-5665
  • Talita Mendes da Silva Ventura Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Bauru, São Paulo http://orcid.org/0000-0003-2101-1350
  • Julio Toshimi Doyama Universidade Estadual Paulista Júlio de Mesquita Filho, Campus Botucatu, Rubião Jr, São Paulo http://orcid.org/0000-0001-9456-4111
  • Willian Fernando Zambuzzi Universidade Estadual Paulista Júlio de Mesquita Filho, Campus Botucatu, Rubião Jr, São Paulo http://orcid.org/0000-0002-4149-5965
  • Rodrigo Cardoso de Oliveira Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Bauru, São Paulo http://orcid.org/0000-0003-3070-5960

DOI:

https://doi.org/10.1590/1678-7757-2018-0596

Keywords:

Extracellular matrix, Matrix metalloproteinases, Bone, Vascular calcification, Extracellular vesicles

Abstract

Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer.

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Published

2021-09-20

Issue

Vol. 27 (2019)

Section

Review

License

Copyright (c) 2021 Journal of Applied Oral Science

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Todo o conteúdo do periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons do tipo atribuição CC-BY.

 

 

How to Cite

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases. (2021). Journal of Applied Oral Science, 27, e20180596. https://doi.org/10.1590/1678-7757-2018-0596