FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

  • Saulo Gabriel Moreira FALCI Federal University of Vales do Jequitinhonha e Mucuri; College of Basic Sciences and Health; Department of Dentistry
  • Ana Terezinha Marques MESQUITA Federal University of Vales do Jequitinhonha e Mucuri; College of Basic Sciences and Health; Department of Dentistry
  • Bruno Augusto Benevenuto de ANDRADE Fluminense Federal University; School of Dentistry
  • Joao Luiz de MIRANDA Federal University of Vales do Jequitinhonha e Mucuri; College of Basic Sciences and Health; Department of Dentistry
  • Jorge Esquiche LEÓN University of São Paulo; Public Oral Health and Forensic Dentistry; Department of Stomatology
  • Oslei Paes de ALMEIDA University of Campinas; Piracicaba Dental School; Oral Pathology Section; Department of Oral Diagnosis
  • Cássio Roberto Rocha dos SANTOS Federal University of Vales do Jequitinhonha e Mucuri; College of Basic Sciences and Health; Department of Dentistry

Abstract

Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance.

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Published
2014-04-01
Section
Original Articles