Transmissão de verrugas anogenitais em crianças e associação com abuso sexual

Autores

  • Jefferson Drezett Hospital Pérola Byington; Centro de Referência da Saúde da Mulher; Núcleo de Violência Sexual e Abortamento
  • Raquel Molina de Vasconcellos Hospital Pérola Byington; Centro de Referência da Saúde da Mulher; Núcleo de Violência Sexual e Abortamento
  • Daniela Pedroso Hospital Pérola Byington; Centro de Referência da Saúde da Mulher; Núcleo de Violência Sexual e Abortamento
  • Marcia de Toledo Blake Faculdade de Medicina do ABC; Laboratório de Escrita Científica
  • Adriana Gonçalves de Oliveira Faculdade de Medicina do ABC; Laboratório de Escrita Científica
  • Luiz Carlos de Abreu Faculdade de Medicina do ABC; Laboratório de Escrita Científica

DOI:

https://doi.org/10.7322/jhgd.20047

Palavras-chave:

infecções por papillomavirus, maus-tratos sexuais infantis, condiloma acuminado, transmissão vertical de doença infecciosa, violência doméstica

Resumo

INTRODUÇÃO: A incidência do condiloma acuminado anogenital em crianças mostra notável aumento nas últimas duas décadas, bem como o interesse por sua associação com o abuso sexual. No entanto, essa relação apresenta controvérsias quanto à etiologia da infecção, o que torna o atendimento desafiador, particularmente nos aspectos ético-legais. OBJETIVO: Revisão da literatura sobre transmissão do HPV em crianças e relação com abuso sexual. MÉTODO: Síntese de dados da consulta ao Journal Citation Reports (JCR-ISI), Medical Literature Analysis and Retrieval System Online (Medline), Scientific Eletronic Library Online (Scielo) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (Lilacs). Foram utilizados descritores MeSH Terms com sintaxes (HPV [All Fields]) AND ("Child Abuse, Sexual" [MeSH Terms]). Artigos relevantes entre 1989 e 2009 foram selecionados. Aspectos ético-legais foram consultados na legislação penal e Estatuto da Criança e do Adolescente. RESULTADOS: Diferentes formas de transmissão não sexual do HPV em crianças estão documentadas, destacando-se a transmissão vertical, auto e heteroinoculação de verrugas cutâneas, e aquisição por instrumentos. Estudos são discordantes quanto à aplicabilidade do DNA-HPV para diferenciar a transmissão sexual e não sexual das verrugas anogenitais. CONCLUSÃO: Evidências indicam que em crianças com menos de dois anos de idade a transmissão não sexual do HPV deve ser fortemente considerada na ausência de lesões genitais, de outra DST, ou de história consistente de abuso. A probabilidade de associação entre HPV e abuso sexual aumenta diretamente com a idade, principalmente após os cinco anos.

Referências

Gilbert R, Widom CS, Brown K, Fergusson D, Webb E, Janson S. Burden and consequences of child maltreatment in high-income countries. Lancet, 2009;373(9657):68-81.

Gavin L, MacKay AP, Brown K, Harrier S, Ventura SJ, Kann L, et al. Sexual and reproductive health of persons aged 10-24 years – United States, 2002-2007. MMWR Surveill Summ,2009;58(6):1-58.

Sapp MV, Vandeven AM. Update on childhood sexual abuse. Curr. Opin Pediatr, 2005; 17(2):258-264.

Berkoff MC, Zolotor AJ, Makoroff KL, Thackeray JD, Shapiro RA, Runyan DK. Has this pre-pubertal girl been sexually abused? JAMA. 2008; 300 (23): 2779-2792.

Drezett J, Caballero M, Juliano I, Prieto ET, Marques JA, Fernandes CE. Study of mechanisms and factors related to sexual abuse infemale children and adolescents. J Pediatr. 2001;77(5):431-9.

Finkelhor D, Hotaling G, Lewis IA, Smith C. Sexual abuse in a national survey of adult men and women: prevalence characteristics and risk factors. Child Abuse Negl, 1990; 14(1): 19-28.

Drezett J, Junqueira L, Tardelli R, Antonio IP, Macedo Jr H, Vertamatti MAF, Pimentel RM, Abreu LC. Influence of forensic examination on the accountability of sexual violence authors in teenagers. Rev Bras Cresc e Desenv Hum.2011;21(2)189-97.

Hornor G. Ano-genital warts in children: se-xual abuse or not? J Pediatr Health Care. 2004;18(4):165-70.

Hammerschlag MR, Guillén CD. Medical and legal implications of testing for sexual lytransmitted infections in children. Clin Microbiol Rev, 2010; 23(3): 493-506.

Siegfried E, Rasnick-Conley J, Cook S, Leonar-di C, Monteleone J. Human papillomavirus screening in pediatric victims of sexual abuse. Pediatrics, 1998;101(1Pt1):43-7.

Bechtel K. Sexual abuse and sexually transmitted infections in children and adolescents. Curr Opin Pediatr, 2010; 22(1): 94-9.

Kellogg N. The evaluation of sexual abuse in children. Pediatrics, 2005;116(2):506-12.

Glaser JB, Hammerschlag MR, Mccormack WM. Epidemiology of sexually transmitted diseases in rape victims. J Infect Dis, 1989; 11(2): 246-54.

Ingram DL, Everett VD, Lyna PR, White ST, Rockwell LA. Epidemiology of adult sexually transmitted disease agents in children being evaluated for sexual abuse. Pediatr Infect DisJ, 1992;11(11):945-50.

Girardet RG, Lahoti S, Howard LA, Fajman NN, Sawyer MK, Driebe EMet al. The epidemiology of sexually transmitted infections in suspected child victims of sexual assault. Pediatrics,2009;124(1):79-86.

Syrjanen S, Puranen M. Human papillomavirus infections in children; the potential role of maternal transmission. Critical Review of Oral Biological Medicine, 2000;11(2):259-274.

Vanhooteghem O, Müller G, de la Brassinne M. Anogenital condylomata in the children. Practice guidelines for a medical expertise. Rev Med Liege, 2007;62(3):151-4.

Rogo KO, Nyansera PN. Congenital condyloma ta acuminate with meconium staining of amniotic fluid and fetal hydrocephalus: case report. East Afr Med J, 1989;66(6):411-413.

Obalek S, Jablonska S, Favre M, Walczak L, Orth G. Condylomata acuminate in children: frequent association with human papillomaviruses responsible for cutaneous warts. J Am Acad Dermatol, 1990; 23(2Pt1): 205-13.

Handley J, Dinsmore W, Maw R, Corbett R, Bur-rows D, Bharucha H, Swann A, Bingham A. Anogenital warts in prepubertal children: sexual abuse or not? Int J STD AIDS,1993;4(5):271-9.

Cason J, Kaye JN, Jewers RJ, Kambo PK, BibleJM, Kell B, et al. Perinatal infection and persistence of human papillomavirus types 16 and 18in infants. I Med Virol, 1995;47(3):209-218.

Smith EM, Johnson SR, Cripe T, Perlman S, McGuinness G, Jiang D, et al. Perinatal transmission and maternal risks of human papillomavirus infection. Cancer Detect Prevent, 1995;19(2):196-205.

Puranen M, Yliskoski M, Saarikoski S, SyrjanenK, Syrjanen S. Exposure of an infant to cervical human papillomavirus infection of the mother is common. Am I Obstet Gynecol, 1997;176(5):1039-1045.

Frazier L. Genital warts in children. The American Professional Society of the Abuse of Children Advisor, 1998; 11:9-12.

Kui LL, Xiu HZ, Ning LY. Condyloma acuminate and human papilloma virus infection in the oral mucosa of children. Pediatr Dent,2003;25(2):149-53.

Myhre AK, Dalen A, Berntzen K, BratlidD. Anogenital human papillomavirus in non-abused preschool children. Acta Pediatr,2003;92(12):1445-52.

Cheung PC, Ko CH, Lee HY, Ho LM, To WW. Correlation of colposcopic anogenital findings and overall assessment of child sexual abuse: prospective study. Hong Kong Med J,2004; 10(6):378-83.

Simmons KJ, Hicks DJ. Child sexual abuse examination: is there a need for routine screening for N. gonorrhoeae and C. trachomatis. J. Pediatr Adolesc Gynecol, 2005;18(5):343-345.

Marcoux D, Nadeau K, McCuaig C, Powell J, Oligny LL. Pediatric anogenital warts: a 7-yearreview of children referred to a tertiary-care hospital in Montreal, Canada. Pediatr Derma-tol, 2006;23(3):199-207.

Jones V, Smith SJ, Omar HA. Nonsexual trans-mission of anogenital warts in children: a retrospective analysis. ScientificWorldJournal,2007; 7: 1896-9.

Derksen DJ. Children with condylomata acuminate. J FamPract, 1992; 34(4): 419-23.

Slaughter L, Brown CR. Colposcopy to establish physical findings in rape victims. Am J Obstet Gynecol, 1992; 166(1Pt1):83-6.

Gutman LT, St Claire KK, Everett VD, Ingram DL, Soper J, Johnston WW, Mulvaney GG, Phelps WC. Cervical-vaginal and intraanal human papillomavirus infection of young girls with external genital warts. J Infect Dis,1994;170(2):339-44.

Stevens-Simon C, Nelligan D, Breese P, JennyC, Douglas JM Jr. The prevalence of genital human papillomavirus infections in abused and Nona bused preadolescent girls. Pediatrics,2000;106(4):645-9.

Jesus LE, Cirne Neto OL, Monteiro do Nascimento LM, Costa Araújo R, Agostinho Baptista A. Anogenital warts in children: sexual abuse or inintencional contamination? Cad Saude Publica, 2001;17(6):1383-91.

Sinclair KA, Woods CR, Kirse DJ, Sinal SH. Anogenital and respiratory tract human papillomavirus infections among children: age, gender, and potential transmission through sexual abuse. Pediatrics, 2005; 116(4): 815-25.

Wingood GM, Seth P, DiClemente RJ, Robinson LS. Association of sexual abuse with incident high-risk human papillomavirus infection among young African-American women. SexTransm Dis, 2009;36(12):784-6.

Vanchiere J, Demmer G. Human polyomaviruses and papillomaviruses. In: Feigin R, Cherry J, Demmler G, Kaplan S, eds. Textbook of Pediatric Infectious Diseases. 5th ed. Philadelphia, PA: Saunders; 2004: 1809–1831.

Carr J, Gyorfi T. Human papillomavirus: epidemiology, transmission, and pathogenesis. Clinics in Laboratory Medicine, 2000;20(2):235–254.

Estreich S, Forster GE, Robinson A. Sexually transmitted diseases in rape victims. Genitourin Med, 1990; 66(6):433-8.

Jenny C, Hooton TM, Bowers A, Copass MK, Krieger JN, Hillier SL, et al. Sexually transmitted diseases in victims of rape. N Engl J Med,1990; 322(11): 713-6.

Lacey HB. Sexually transmitted diseases and rape: the experience of a sexual assault centre. Int J STD AIDS, 1990;1(6):405-9.

Bell TA, Stamm WE, Wang SP, Holmes KK, Grays-ton JT. Chronic Chlamydia trachomatis infections in infants. JAMA, 1992;267(3):400-402.

Handley J, Hanks E, Armstrong K, Bingham A, Dinsmore W, Swann A, Evans MF, McGee JO, O’Leary J. Common association of HPV 2 with anogenital warts in prepubertal children. Pediatr Dermatol, 1997; 14(5): 339-43.

Hymel KP, Jenny C. Child sexual abuse. Del Med J, 1997;69(8):415-29.

Rehme MFB, Carvalho NS, Ihlenfeld MFK, Chuery ACS. Condiloma acuminado em crianças e adolescentes. Rev Bras Ginecolobstet, 1998;20(7): 377-80.

American Professional Society on the Abuse of Children. Sexual abuse of children. In: Myers J, Berliner L, Briere J, Hendrix C, Jenny C, Reid T, editors. The APSAC handbook on child maltreatment. 2nd ed. Thousand Oaks Sage; 2001.p55-78.

Goldenring JM. Secondary syphilis in a prepubertal child.Differentiating condyloma lata fromcondyloma acuminata. N Y State J Med, 1989;89(3): 180-1.

Delmanto C, Delmanto R, Delmanto-Jr R, Del-manto FMA, editores. Código penal comentado. São Paulo: Saraiva; 2010.

Estatuto da Criança e do Adolescente. São Paulo: Imprensa Oficial do Estado de São Paulo;2008.

Atabaki S, Paradise JE. The medical evaluation of the sexually abused child: Lessons from a decade of research. Pediatrics, 1999; 104:178-86.

Publicado

2012-04-01

Edição

Seção

Pesquisa Original