Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication

  • Fábio dos Santos Schlottfeldt Universidade de São Paulo; Escola de Enfermagem
  • Sheila Marques Fernandes Universidade de São Paulo; Escola de Enfermagem
  • Daniel Malisani Martins Universidade de São Paulo; Escola de Enfermagem
  • Priscilla Cordeiro Universidade de São Paulo; Escola de Enfermagem
  • Cassiane Dezoti da Fonseca Universidade de São Paulo; Escola de Enfermagem
  • Mirian Watanabe Universidade de São Paulo; Escola de Enfermagem
  • Maria de Fatima Fernandes Vattimo Universidade de São Paulo; Escola de Enfermagem; Departamento de Enfermagem Médico Cirúrgica

Abstract

Objective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys.

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Published
2015-12-01
How to Cite
Schlottfeldt, F., Fernandes, S., Martins, D., Cordeiro, P., Fonseca, C., Watanabe, M., & Vattimo, M. (2015). Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication . Revista Da Escola De Enfermagem Da USP, 49(spe), 74-79. https://doi.org/10.1590/S0080-623420150000700011
Section
Original Articles