PT-BR: Radioterapia PSMA-ligante dirigida com Lutécio 177 como um tratamento para câncer de próstata resistente a castração: uma revisão sistemática

Autores

DOI:

https://doi.org/10.11606/issn.1679-9836.v100i4p391-402

Palavras-chave:

Neoplasias da próstata, 177Lu-PSMA, Câncer de próstata resistente à castração, Eficácia, Metástase neoplásica, Antígeno de membrana específico da próstata, Terapia com radioligantes, Segurança, Dosimetria, Medicina nuclear

Resumo

O câncer de próstata é o segundo mais prevalente no mundo, sendo uma importante causa de mortalidade dentre homens idosos. Sua forma mais séria é o câncer metastático resistente a terapia hormonal, sendo difícil de controlar pois não responde tanto a quimioterapia quanto a privação de androgénos. Um novo tratamento, baseado em moléculas ligantes de PSMA, quelado ao átomo Lutécio-177, é uma terapia potencial para esse perfil de paciente, com evidências que esta causa regressão tumoral. O objetivo dessa revisão sistemática é avaliar a segurança e eficiência dessa nova terapia baseada na literatura atual

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Biografia do Autor

Lucca Paolo Hsu Helmich, Universidade de São Paulo. Faculdade de Medicina

Medical student at Faculdade de Medicina da Universidade de São Paulo – FMUSP.

Marcelo Augusto Magalhães de Arruda, Universidade de São Paulo. Faculdade de Medicina

Medical student at Faculdade de Medicina da Universidade de São Paulo – FMUSP.

Marcelo Tatit Sapienza, Universidade de São Paulo. Faculdade de Medicina

Associate Professor, Instituto de Radiologia do Hospital das Clínicas da Universidade de São Paulo.

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Publicado

2021-10-04

Como Citar

Helmich, L. P. H., Arruda, M. A. M. de, & Sapienza, M. T. (2021). PT-BR: Radioterapia PSMA-ligante dirigida com Lutécio 177 como um tratamento para câncer de próstata resistente a castração: uma revisão sistemática. Revista De Medicina, 100(4), 391-402. https://doi.org/10.11606/issn.1679-9836.v100i4p391-402

Edição

Seção

Artigos de Revisão/Review Articles