Transformação leucêmica do microambiente das células-tronco hematopoiéticas
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i6e-174413Palavras-chave:
Microambiente tumoral, Leucemia, Hematopoese, Células-troncoResumo
O microambiente das células-tronco hematopoiéticas é responsável por coordenar diversos eventos envolvidos na produção de células sanguíneas. Essa renovação hematopoiética só é possível graças às interações e sinalizações bem ordenadas que mantém a harmonia do tecido. Nas leucemias ocorre ruptura nesses mecanismos de controle e ocorre processo de transformação leucêmica do microambiente, de forma a favorecer a manutenção neoplásica do tecido sanguíneo. O objetivo deste estudo foi expor o processo de transformação leucêmica do microambiente, no âmbito das modificações celulares e moleculares sofridas para sustentar o tumor. Trata-se de um artigo de revisão narrativa e as bases de dados Pubmed, Scielo, Cocrahne Library e MedLine foram consultadas em busca de publicações dos últimos anos sobre o tema. Os dados apresentados contribuem para o entendimento holístico acerca das leucemias. A transformação leucêmica, seja por mutações primárias nos componentes do microambiente ou pelo sequestro de suas funções normais pelas células iniciadoras de leucemia, é relevante para que ocorra a instalação, a progressão, a disseminação e a quimiorresistência tumoral. Por meio da atuação de vários componentes este microambiente sustenta as células-tronco leucêmicas e representa caminho promissor para o desenvolvimento de novas terapias antileucêmicas.
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Copyright (c) 2022 Maria Thereza Carvalho Rodriguez Guisande, Lorrany Junia Lopes de Lima, Gabriel Santos Costa, Jarbas Delmoutiez Ramalho Sampaio Filho, Matheus Rodrigues Lopes
Este trabalho está licenciado sob uma licença Creative Commons Attribution-ShareAlike 4.0 International License.
