Autologous Anti-CD19 CAR T-Cells immunotherapy in relapsed/refractory acute lymphoblastic leukemia patients. A systematic review and meta-analysis




Immunotherapy, Anti-CD19 CAR T-Cells, Acute Lymphoblastic Leukemia, Antígenos CD19


Introduction: Acute Lymphoblastic Leukemia (ALL) is the most prevalent malignancy in children; however, when the neoplasm becomes refractory/relapses (R/R) the cure possibilities are practically null. Objectives: To analyze the Anti-CD19 Chimeric Antigen Receptors (CAR) T-Cells immunotherapy efficacy in the treatment of R/R ALL, providing evidence about the efficacy and safety of the therapy for the analyzed group. Methods: The study consisted of a systematic review and meta-analysis based on the analysis of indexed articles. The searches were carried out with the terms: “acute lymphoblastic leukemia”, “CAR T”, and “CD19-specific chimeric antigen receptor”. Results: Only 18 of the 94 articles obtained initially met the inclusion criteria and were selected for review, totaling 637 patients. Thus, it was observed in the responses that approximately 81% of the patients achieved a Complete Response; 7% did not respond; the neoplasm relapsed in 17% of the cases; and 6.1% of the patients died. The main side effects found were Cytokine Release Syndrome (CRS), Severe Cytokine Release Syndrome, and Neurotoxicity, present in 36.3%, 29%, and 24% of patients, respectively. Conclusion: Anti-CD19 CAR T-Cells immunotherapy is an effective therapy, capable of producing high rates of complete remission in R/R ALL treatment.


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Biografia do Autor

Maria Cristina Figueroa Magalhães, Pontifícia Universidade Católica do Paraná

Pontifícia Universidade Católica do Paraná, Escola de Medicina, Curitiba, PR, Brasil. Hospital Universitário Evangélico Mackenzie, Serviço de Oncologia Clínica, Curitiba, PR, Brasil. Grupo Oncoclínicas / Instituto de Hematologia e Oncologia Curitiba, Serviço de Oncologia Clínica, Curitiba, PR, Brasil.


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Como Citar

Pasquini Neto, R., Mazzo, F. A. T. ., Bueno, G. de S., Previdi, J. V. C., Silva, N. K. B. da, Vieira, T. da S., & Magalhães, M. C. F. (2022). Autologous Anti-CD19 CAR T-Cells immunotherapy in relapsed/refractory acute lymphoblastic leukemia patients. A systematic review and meta-analysis. Revista De Medicina, 101(5), e-181721.



Artigos de Revisão/Review Articles