Biomarcadores de sepse: uma revisão do valor diagnóstico da presepsina
DOI:
https://doi.org/10.11606/issn.1679-9836.v102i1e-182916Palavras-chave:
Biomarcadores, Sepse, Diagnóstico, Presepsina, Procalcitonina, PCRResumo
A sepse é uma síndrome prevalente e com alta morbimortalidade, sendo necessário um método diagnóstico precoce e eficaz. Estudos recentes sugerem que a presepsina pode ser um potencial biomarcador para o diagnóstico de sepse e que tem um desempenho melhor do que outros biomarcadores mais consolidados, como procalcitonina e PCR. Esta revisão sistemática tem como objetivo avaliar a acurácia da presepsina para o diagnóstico de sepse e comparar com a procalcitonina e a proteína-C-reativa. Uma pesquisa sistemática abrangente foi conduzida no PubMed e na Biblioteca Virtual em Saúde para coletar estudos publicados nos últimos dois anos com foco na precisão diagnóstica da presepsina para sepse. Oito estudos foram selecionados. Todos eles sugeriram que a presepsina tem algum valor diagnóstico para sepse. Em quatro estudos, a presepsina teve um desempenho melhor do que a procalcitonina e em dois a presepsina teve um desempenho melhor do que a PCR. Dois estudos não mostraram diferenças significativas entre a presepsina e os outros biomarcadores. Esta revisão indica que a presepsina pode ter valor significativo para o diagnóstico precoce da sepse, corroborando para aumentar a eficiência de ferramentas existentes, como a PCR e a procalcitonina. No entanto, mais estudos são necessários para confirmar sua eficácia como um único marcador de diagnóstico.
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Copyright (c) 2023 Thalissa Ferreira, Marcelo Arruda Candido, Francisco Garcia Soriano
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