Male infertility in patients diagnosed with COVID-19: a narrative review
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i1e-185913Palavras-chave:
Infections. COVID-19. Infertility.Viruses. SARS-CoV-2Resumo
Introduction: Literature reports on the potential impact of the coronavirus 2019 (COVID-19) on male reproductive organs and male fertility. Objective: To present scientific evidence, based on a narrative review, of the association of male infertility in patients diagnosed with COVID-19. Materials and Methods: The articles were searched in the SciELO, LILACS, PubMed, Scopus, BIREME and Web of Science databases, without restriction of location or language. The period established for the evaluation was from 2015 to 2020. The studies were selected through combinations based on Medical Subject Headings (MeSH). Two studies that answered the research question were included in this research; its score was ≥ 6 points in the qualitative protocol proposed by Pithon et al.7. Results: The angiotensin-2 converting enzyme receptor, facilitates the COVID-19 virus to infiltrate host cells, is intensely expressed in testicular cells. Furthermore, inflammatory responses induced by COVID-19 infection can lead to systemic oxidative stress. Conclusion: The testes are a potential target of COVID-19, resulting in testicular damage. Therefore, the immediate or late impacts on male fertility brought about by COVID-19 cannot be ruled out. Definitive data to track reproductive functions in men who have recovered from COVID-19 have not yet been obtained, although studies are underway to establish this association in male health.
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Copyright (c) 2022 Laura Gonçalves Fustino, Janaina Viana Stolz, Patricia Haas
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