Manifestações neurológicas da COVID-19 na população pediátrica - revisão de literatura e desenvolvimento de casos clínicos com finalidades didáticas
DOI:
https://doi.org/10.11606/issn.1679-9836.v102iespe-203953Palavras-chave:
Manifestações Neurológicas, COVID-19, Adolescente, Criança, Lactente, Aprendizagem Baseada em Problemas, Educação MédicaResumo
O COVID-19 é uma síndrome respiratória aguda com diferentes sintomas não respiratórios relatados, incluindo manifestações neurológicas. O comprometimento do sistema nervoso durante a infecção ocorre em adultos e crianças, porém a população pediátrica apresenta particularidades no curso clínico da doença. Discutimos as manifestações neurológicas da COVID-19 em crianças, desenvolvendo casos para serem aplicados em disciplinas dentro da metodologia baseada em problemas. A pesquisa foi desenvolvida tendo em vista os graduandos em medicina: foi realizada uma revisão da literatura sobre o tema; em seguida, observado pela seleção de 16 artigos revisados, resumidos e discutidos. Este artigo discute os procedimentos, desafios e resultados de cada etapa da agenda de pesquisa. Na revisão da literatura encontramos diferentes manifestações neurológicas na população pediátrica. Outros aspectos relevantes ao tema também foram encontrados, como: associação de comorbidades, alterações em exames complementares, prognósticos e hipóteses fisiopatológicas. Com base nos achados, criamos três casos clínicos para aplicação na graduação. Concluímos que o tema tem grande importância clínica e de aprendizado, mas ainda são necessárias mais pesquisas sobre o assunto.
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Annex References
Lin JE, Asfour A, Sewell TB, Hooe B, Pryce P, Earley C, et al. Neurological issues in children with COVID-19. Neurosci Lett. 2021;743(December 2020):135567. https://doi.org/10.1016/j.neulet.2020.135567
Panda PK, Sharawat IK, Panda P, Natarajan V, Bhakat R, Dawman L. Neurological complications of SARS-CoV-2 infection in children: a systematic review and meta-analysis. J Trop Pediatr. 2021;67(3):1-11. https://doi.org/10.1093/tropej/fmaa070
Siracusa L, Cascio A, Giordano S, Medaglia AA, Restivo GA, Pirrone I, et al. Neurological complications in pediatric patients with SARS-CoV-2 infection: a systematic review of the literature. Ital J Pediatr. 2021;47(1). https://doi.org/10.1186/s13052-021-01066-9
Raj SL, Vasanthi T, Bainensomui SR. Neurological manifestations of COVID-19 in children SARS-CoV- 2 encephalitis in an adolescent girl. Indian Pediatr. 2020;57:1185–6. https://doi.org/10.1016/S2352-4642(21)00193-0
Lindan CE, Mankad K, Ram D, Kociolek LK, Silvera VM, Boddaert N, et al. Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study. Lancet Child Adolesc Heal. 2021;5(3):167-77. https://doi.org/10.1016/S2352-4642(20)30362-X
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