SUSCEPTIBILITY TEST FOR FUNGI: CLINICAL AND LABORATORIAL CORRELATIONS IN MEDICAL MYCOLOGY

Authors

  • Ana ALASTRUEY-IZQUIERDO Instituto de Salud Carlos III; National Centre for Microbiology
  • Marcia S.C. MELHEM Instituto Adolfo Lutz
  • Lucas X. BONFIETTI Instituto Adolfo Lutz
  • Juan L. RODRIGUEZ-TUDELA Global Action Fund for Fungal Infections

Abstract

During recent decades, antifungal susceptibility testing has become standardized and nowadays has the same role of the antibacterial susceptibility testing in microbiology laboratories. American and European standards have been developed, as well as equivalent commercial systems which are more appropriate for clinical laboratories. The detection of resistant strains by means of these systems has allowed the study and understanding of the molecular basis and the mechanisms of resistance of fungal species to antifungal agents. In addition, many studies on the correlation of in vitro results with the outcome of patients have been performed, reaching the conclusion that infections caused by resistant strains have worse outcome than those caused by susceptible fungal isolates. These studies have allowed the development of interpretative breakpoints for Candida spp. and Aspergillus spp., the most frequent agents of fungal infections in the world. In summary, antifungal susceptibility tests have become essential tools to guide the treatment of fungal diseases, to know the local and global disease epidemiology, and to identify resistance to antifungals.

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Published

2015-09-01

How to Cite

ALASTRUEY-IZQUIERDO, A., MELHEM, M. S., BONFIETTI, L. X., & RODRIGUEZ-TUDELA, J. L. (2015). SUSCEPTIBILITY TEST FOR FUNGI: CLINICAL AND LABORATORIAL CORRELATIONS IN MEDICAL MYCOLOGY . Revista Do Instituto De Medicina Tropical De São Paulo, 57(suppl.19), 57-64. Retrieved from https://www.revistas.usp.br/rimtsp/article/view/105846

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