In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection

Authors

  • Ana Paula Carvalho Reis Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Micologia Médica
  • Franciele Fernandes Correia Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Micologia Médica
  • Thais Martins Jesus Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Micologia Médica
  • Carla Pagliari Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, Laboratório da Disciplina de Patologia de Moléstias Transmissíveis
  • Neusa Y. Sakai-Valente Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Clínica Dermatológica, Laboratório de Investigação Médica LIM 53
  • Walter Belda Júnior Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Clínica Dermatológica, Laboratório de Investigação Médica LIM 53
  • Paulo Ricardo Criado Faculdade de Medicina do ABC
  • Gil Benard Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Micologia Médica
  • Maria Gloria Teixeira Sousa Universidade de São Paulo, Instituto de Medicina Tropical, Laboratório de Micologia Médica https://orcid.org/0000-0003-4157-1945

DOI:

https://doi.org/10.1590/S1678-9946201961056

Keywords:

Dermatophytosis, Innate immune response, Langerhans cells, Macrophages, CD68 , Factor XIIIa , CD1a , Trichophyton rubrum

Abstract

Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis.

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Published

2019-10-09

Issue

Vol. 61 (2019)

Section

Original Articles

How to Cite

Reis, A. P. C., Correia, F. F., Jesus, T. M., Pagliari, C., Sakai-Valente, N. Y., Belda Júnior, W., Criado, P. R., Benard, G., & Sousa, M. G. T. (2019). In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection. Revista Do Instituto De Medicina Tropical De São Paulo, 61, e56. https://doi.org/10.1590/S1678-9946201961056