Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population

Authors

  • Ana Maria Almeida Silva Carvalho Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil
  • Danielle Salgado de Brito Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil
  • Ana Paula Almeida Cunha Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil
  • Pablo de Matos Monteiro Universidade Federal do Maranhão, Departamento de Farmácia, São Luís, Maranhão, Brazil http://orcid.org/0000-0002-3879-5326
  • Mariele Borges Ferreira Universidade Federal do Maranhão, Departamento de Farmácia, São Luís, Maranhão, Brazil
  • Diogo Souza Ferreira Rubim de Assis Universidade Federal do Maranhão, Departamento de Morfologia, São Luís, Maranhão, Brazil
  • Janaína Oliveira Bentivi Universidade Federal do Maranhão, Departamento de Medicina I, São Luís, Maranhão, Brazil
  • Marcelo Souza de Andrade Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil Universidade Federal do Maranhão, Departamento de Fisiologia, São Luís, Maranhão, Brazil
  • Flávia Castello Branco Vidal Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil Universidade Federal do Maranhão, Departamento de Farmácia, São Luís, Maranhão, Brazil Universidade Federal do Maranhão, Departamento de Morfologia, São Luís, Maranhão, Brazil http://orcid.org/0000-0002-4721-6824
  • Natalino Salgado Filho Universidade Federal do Maranhão, Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil Universidade Federal do Maranhão, Departamento de Medicina I, São Luís, Maranhão, Brazil

DOI:

https://doi.org/10.1590/S1678-9946202163063

Keywords:

Recurrent respiratory papillomatosis, Human papillomavirus, Genotype, Larynx

Abstract

This study presents 25 cases of recurrent respiratory papillomatosis (RRP) that occurred in Sao Luis, Maranhao State, Northeast region, Brazil, between January 2007 and December 2018. Sociodemographic and clinical profile of patients as well as human papillomavirus (HPV) infection status were evaluated. Clinical and histopathological data were collected from the patients’ medical records. For the HPV infection analysis, DNA was extracted and subjected to amplification by a nested polymerase chain reaction. Viral genotyping was performed by automated sequencing. The median age of patients was 12.40 ± 12.6. years, and the juvenile form of the disease (68%) was the predominant form of disease. Female participants were predominant (60%), and they were from cities located in the interior of the State (60%). The most common clinical manifestation was dysphonia; recurrence was observed in most cases (56%), and tracheostomy was necessary in seven patients (26.9%). When comparing the RRP forms, patients in the juvenile-RRP group had higher recurrence rates and need of tracheostomy than those in the adult-RRP group. The viral genotyping analysis revealed that 47.8% of patients had low-risk HPVs, whereas 13.1% had high-risk HPVs, and in 39.1% of patients the viral genotype was not obtained. HPV-6 was the most prevalent type and Juvenile-RRP was more prevalent in our population. HPV was present at a high rate, and HPV-6 was the predominant genotype. This study serves as the basis for further studies to be conducted in the Brazilian population. Our findings aid the better understanding of RRP, possibly suggesting some prognostic factors associated with the disease aggressiveness.

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Published

2021-09-21

Issue

Section

Original Article

How to Cite

Recurrent respiratory papillomatosis: clinical characteristics and viral genotyping in a Brazilian population. (2021). Revista Do Instituto De Medicina Tropical De São Paulo, 63, e63. https://doi.org/10.1590/S1678-9946202163063