Silent circulation of Chikungunya virus among pregnant women and newborns in the Western Brazilian Amazon before the first outbreak of chikungunya fever

Authors

  • Kelly Aparecida Kanunfre Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, São Paulo, Brazil http://orcid.org/0000-0002-7845-7110
  • Mussya Cisotto Rocha Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, São Paulo, Brazil Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Imunologia (LIM 48), São Paulo, São Paulo, Brazil http://orcid.org/0000-0003-3577-1801
  • Maíra Barreto Malta Universidade de São Paulo, Faculdade de Saúde Pública, Departamento de Nutrição, São Paulo, São Paulo, Brazil Universidade Católica de Santos, Programa de Pós-Graduação em Saúde Pública, Santos, São Paulo, Brazil http://orcid.org/0000-0003-4993-1589
  • Rodrigo Medeiros de Souza Universidade Federal do Acre, Campus Floresta, Cruzeiro do Sul, Acre, Brazil http://orcid.org/0000-0002-7775-6901
  • Marcia Caldas Castro Harvard T. H. Chan School of Public Health, Department of Global Health and Population, Boston, Massachusetts, USA http://orcid.org/0000-0003-4606-2795
  • Silvia Beatriz Boscardin Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, São Paulo, Brazil http://orcid.org/0000-0002-7845-7110
  • Higo Fernando Santos Souza Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, São Paulo, São Paulo, Brazil http://orcid.org/0000-0002-1095-951X
  • Steven S. Witkin Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Virologia (LIM 52), São Paulo, São Paulo, Brazil Weill Cornell Medicine, Obstetrics and Gynecology, New York, New York, USA http://orcid.org/0000-0002-3502-3929
  • Marly Augusto Cardoso Universidade de São Paulo, Faculdade de Saúde Pública, Departamento de Nutrição, São Paulo, São Paulo, Brazil http://orcid.org/0000-0003-0973-3908
  • Thelma Suely Okay Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia, São Paulo, São Paulo, Brazil Universidade de São Paulo, Faculdade de Medicina, Departamento de Pediatria, São Paulo, São Paulo, Brazil http://orcid.org/0000-0001-9316-7288

DOI:

https://doi.org/10.1590/S1678-9946202264025

Keywords:

CHIKV, Seroprevalence, Asymptomatic infection, IgG antibodies, Pregnancy, Neonates, Amazon region

Abstract

The prevalence of immunity to Chikungunya virus (CHIKV) in pregnant women and newborns in the Western Brazilian Amazon was assessed at a time when previous studies did not report chikungunya fever in the area. In 435 asymptomatic pregnant women and 642 healthy unrelated newborns, the presence of IgM and IgG antibodies to CHIKV were determined by a commercial ELISA. All participants were negative to IgM anti-CHIKV. Anti-CHIKV IgG was identified in 41 (9.4%) pregnant women and 66 (10.3%) newborns. The presence of anti-CHIKV IgG was positively associated with the lowest socioeconomic status in pregnant women (OR 2.54, 95% CI 1.15-5.62, p=0.021) and in the newborns’ mothers (OR 5.10, 95% CI 2.15-12.09, p< 0.001). Anti-CHIKV IgG was also associated with maternal age in both, the pregnant women (OR 1.06, 95% CI 1.00-1.11, p=0.037) and the newborns’mothers (OR 1.08, 95% CI 1.03-1.12, p=0.001). Pregnancy outcomes in which the mother or the newborn was anti-CHIKV IgG positive proceeded normally. Negative CHIKV serology was associated with being positive for DENV antibodies and having had malaria during pregnancy. These findings showed that there was already a silent circulation of CHIKV in this Amazon region before the first outbreak of chikungunya fever. Furthermore, seropositivity for CHIKV was surprisingly frequent (10%) in both, pregnant women and newborns, affecting mainly low-income women.

Downloads

Download data is not yet available.

Downloads

Published

2022-05-16

How to Cite

Kanunfre, K. A. ., Rocha, M. C. ., Malta, M. B. ., Souza, R. M. de ., Castro, M. C. ., Boscardin, S. B. ., Souza, H. F. S. ., Witkin, S. S. ., Cardoso, M. A. ., & Okay, T. S. . (2022). Silent circulation of Chikungunya virus among pregnant women and newborns in the Western Brazilian Amazon before the first outbreak of chikungunya fever. Revista Do Instituto De Medicina Tropical De São Paulo, 64, e25. https://doi.org/10.1590/S1678-9946202264025

Issue

Section

Original Article