SARS-CoV-2 in saliva, viremia and seroprevalence for COVID-19 surveillance at a single hematopoietic stem cell transplantation center: a prospective cohort study
DOI:
https://doi.org/10.1590/S1678-9946202264039%20Keywords:
COVID-19, SARS-CoV-2, Hematopoietic stem cell transplantation, Healthcare workersAbstract
This prospective cohort study aims to analyze the surveillance of COVID-19 at a single hematopoietic stem cell transplantation (HSCT) center in Brazil, in 29 patients undergoing allogeneic HSCT and 57 healthcare workers (nurses and dentists), through viral shedding of SARS-CoV-2 in saliva and plasma and seroprevalence of anti-SARS-CoV-2 IgG. In addition, we report two cases with prolonged persistent detection of SARS-CoV-2 without seroconversion. The sample collection was performed seven times for patients and five times for healthcare workers. Only two patients tested positive for SARS-CoV-2 in their saliva and plasma samples (6.9%) without seroconversion. All healthcare workers were asymptomatic and none tested positive. Two patients (6.9%) and four nurses (8%) had positive serology. No dentists had positive viral detection or positive serology. Our results reflect a low prevalence of positive RT-PCR and seroprevalence of SARS-CoV-2 in patients and healthcare workers at a single HSCT center. Results have also corroborated how the rigorous protocols adopted in transplant centers were even more strengthened in this pandemic scenario.
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Copyright (c) 2022 Rafael Zancan Mobile, Stephanie von Stein Cubas Warnawin, Teresinha Keiko Kojo, Jéssica Alline Pereira Rodrigues, Adriana Mendes de Quadros Cavilha, Rodrigo Melim Zerbinati, Douglas Adamoski, Jaqueline Carvalho de Oliveira, Marcelo Santos Conzentino, Luciano Fernandes Huergo, Daniela Fiori Gradia, Paulo Henrique Braz-Silva, Juliana Lucena Schussel
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.