American trypanosomiasis (Chagas' disease) in conventional and germfree rats and mice

Authors

  • Marcelo E. Silva Universidade Federal de Ouro Preto; Escola de Farmácia; Departamento de Nutrição
  • Elizio A. Evangelista Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Bioquímica Imunologia
  • Jacques R. Nicoli Universidade Federal de Minas Gerais; Instituto de Ciências Biológicas; Departamento de Bioquímica Imunologia
  • Eduardo A. Bambirra UFMG; Faculdade de Medicina; Departamento de Anatomia Patológica
  • Enio C. Vieira UFMG; Faculdade de Medicina; Departamento de Anatomia Patológica

Keywords:

Chagas' disease, Trypanosomiasis, Germfree rats, Germfree mice

Abstract

Germfree (GF) and conventional (CV) CFW (LOB) mice and Wistar and Sprague-Dawley rats were infected with Trypanosoma cruzi. The disease was more severe in the GF than in the CV animals as revealed by: (1) an earlier and more intense parasitemia; (2) a more precocious mortality; (3) a twice enlarged spleen: (4) a more intense cell and tissue parasitism; (5) visceral signs of cardiac failure.

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Published

1987-10-01

Issue

Vol. 29 No. 5 (1987)

Section

Original Articles

How to Cite

Silva, M. E., Evangelista, E. A., Nicoli, J. R., Bambirra, E. A., & Vieira, E. C. (1987). American trypanosomiasis (Chagas’ disease) in conventional and germfree rats and mice . Revista Do Instituto De Medicina Tropical De São Paulo, 29(5), 284-288. https://www.revistas.usp.br/rimtsp/article/view/28532