Clonal variation within a mucosal isolate derived from a patient with Leishmania (Viannia) braziliensis infection

Authors

  • César Augusto Cuba-Cuba University of Brasilia; Núcleo de Medicina Tropical e Nutrição
  • David Evans London School of Hygiene and Tropical Medicine; Department of Medical Parasitology
  • Ana de Cassia Rosa University of Brasilia; Núcleo de Medicina Tropical e Nutrição
  • Philip Davis Marsden University of Brasilia; Núcleo de Medicina Tropical e Nutrição

Keywords:

Leishmania (Viannia) braziliensis, Clonal Variation, Zymodemes, Serodemes

Abstract

Three isolates over 5 years from a patient with persistent relapsing mucosal leishmaniasis due to Leishmania (Viannia) braziliensis and 7 clones from one of these isolates were studied by zymodemes and scrodemes analysis. Results showed evidences of clonal phenotypic variation. Eight isoenzymes markers demonstrated clear differences on Cellulose Acetate (CA) and thin starch gel electrophoresis. Also a panel of specific monoclonal antibodies showed such differences. Our observations provide additional evidence that Leishmania (Viannia) braziliensis is composed by subpopulations of parasites with peculiar biochemical and antigenic characteristics.

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Published

1991-10-01

Issue

Vol. 33 No. 5 (1991)

Section

Original Article

How to Cite

Cuba-Cuba, C. A., Evans, D., Rosa, A. de C., & Marsden, P. D. (1991). Clonal variation within a mucosal isolate derived from a patient with Leishmania (Viannia) braziliensis infection . Revista Do Instituto De Medicina Tropical De São Paulo, 33(5), 343-350. https://www.revistas.usp.br/rimtsp/article/view/28852