Comparative study of adenoviruses with monoclonal antibodies

Authors

  • Terezinha Maria de Paiva Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios
  • Sueko Takimoto Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios
  • María Akíko Ishida Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios
  • María Candida Oliveira de Souza Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios
  • Tuneo Ishimaru Instituto Adolfo Lutz; Laboratório de Vírus Respiratórios
  • Jorge Neumann Universidade de São Paulo; Faculdade de Medicina; Laboratório de Imunologia de Transplantes
  • Jorge Kalil Universidade de São Paulo; Faculdade de Medicina; Laboratório de Imunologia de Transplantes

Keywords:

Adenovirus, Species Specific, Monoclonal antibodies, Adenovirus 4, Antigenic Relationship

Abstract

The obtainment of monoclonal antibodies for adenovirus species 4(Ad4) is described.The specificities of selected monoclonal antibodies were determined by means of viral neutralization test in cell culture, immunofluorescence and Enzyme-Linked Immunosorbent Assay (ELISA), in the presence of the following species of human adenovirus: 1, 2, 5 (subgenus C), 4 (subgenus E), 7 and 16 (subgenus B) and 9 (subgenus D). Two monoclonal antibodies species specific to adenovirus 4 (1CIII and 3DIII) and one monoclonal antibody that cross reacted with adenovirus species 4 and 7 (2HIII) were obtained.

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Published

1992-02-01

Issue

Vol. 34 No. 1 (1992)

Section

Original Article

How to Cite

Paiva, T. M. de, Takimoto, S., Ishida, M. A., Souza, M. C. O. de, Ishimaru, T., Neumann, J., & Kalil, J. (1992). Comparative study of adenoviruses with monoclonal antibodies . Revista Do Instituto De Medicina Tropical De São Paulo, 34(1), 19-26. https://www.revistas.usp.br/rimtsp/article/view/28886