The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities

Authors

  • Maria Cristina dos-Santos Universidade de São Paulo; Instituto de Ciências Biomédicas; Departamento de Imunologia
  • Luís Roberto de Camargo Gonçalves Instituto Butantan; Seção de Fisiopatologia Experimental
  • Consuelo L. Fortes-Dias Fundação Ezequiel Dias
  • Yara Cury Instituto Butantan; Seção de Fisiopatologia Experimental
  • José Maria Gutiérrez Universidad de Costa Rica; Instituto Clodomiro Picado
  • Maria de Fátima D. Furtado Instituto Butantan; Seção de Venenos

Keywords:

Bothrops jararacussu, Soroterapia

Abstract

Myonecrosis is one of the effects of Bothrops jararacussu venom, from which a myotoxin was isolated showing structural homology to phospholipase A2 (PLA2), but without enzimatic activity. Such myotoxic activity is also present in the Crotalus durissus terrificus venom, and is atributed to crotoxin and to PLA2 (crotoxin B), the basic component of the crotoxin complex. The Bothrops jararacussu venom showed three proteins with immunologic identity to PLA2 from crotoxin. The bothropic (AB) and the bothropic/crotalic (AB/C) antivenoms, two commercial polyvalent antivenoms produced at Instituto Butantan, were compared in order to assess their capacity for neutralization of the lethal, hemorrhagic, coagulant and myotoxic activities of Bothrops jararacussu venom. Both antivenoms showed the same level of hemorrhagic activity neutralization. However, AB/C was about three times more efficient than AB in neutralizing the myotoxic activity, and two times more potent for neutralization of lethality and coagulant activity of Bothrops jararacussu venom. These data suggest that the use of AB/C could be of value in the treatment of patients bitten by snakes of this species

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Published

1992-04-01

Issue

Section

Original Article

How to Cite

dos-Santos, M. C., Gonçalves, L. R. de C., Fortes-Dias, C. L., Cury, Y., Gutiérrez, J. M., & Furtado, M. de F. D. (1992). The efficacy of the bothropic/crotalic antivenom on the neutralization of the main Bothrops jararacussu venom activities . Revista Do Instituto De Medicina Tropical De São Paulo, 34(2), 77-83. https://www.revistas.usp.br/rimtsp/article/view/28899