Hepatitis B vaccine - proposal for a standardized assessment of immune response
Keywords:
Hepatitis B, Hepatitis B Vaccine, Anti-HBS, AntibodiesAbstract
The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studiesDownloads
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Published
1992-04-01
Issue
Section
Immunology
How to Cite
Ferraz, M. L. G., Silva, A. E., Yamamoto, M., & Guimaråes, R. X. (1992). Hepatitis B vaccine - proposal for a standardized assessment of immune response . Revista Do Instituto De Medicina Tropical De São Paulo, 34(2), 137-140. https://www.revistas.usp.br/rimtsp/article/view/28907