Evaluation of the therapeutic activity of itraconazole in human and experimental chronic infection by Trypanosoma cruzi

Authors

  • Antonio Augusto Baillot Moreira Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Hertha Barbara Wüllert Telles de Souza Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Vicente Amato Neto Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Luís Matsubara Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Pedro Luiz Silva Pinto Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • José Eduardo Tolezano Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Elizabeth Vizone Nunes Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz
  • Masayuki Okumura Secretaria de Estado da Saúde; Membro do Instituto Adolfo Lutz

Keywords:

Trypanosoma cruzi, Infecções crônicas, experimental e humana, Tratamento, Itraconazol

Abstract

Other authors have demonstrated that itraconazole has antiparasitic activity against Trypanosoma cruzi both in vitro and in animal acute infection. Because of these observations, we decided to evaluate the chronic phase of this protozoal disease, since it is the most important form under a clinical and assistential point of view. We studied an infected mouse model as well as human cases of Chagas' disease. One hundred mg/ kg/day by gastric tube, and 100 or 200 mg/day orally were given, respectively, during three months, without showing any beneficial effect, at least with the adopted methods

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Published

1992-04-01

Issue

Vol. 34 No. 2 (1992)

Section

Therapeutic Assay

How to Cite

Moreira, A. A. B., Souza, H. B. W. T. de, Amato Neto, V., Matsubara, L., Pinto, P. L. S., Tolezano, J. E., Nunes, E. V., & Okumura, M. (1992). Evaluation of the therapeutic activity of itraconazole in human and experimental chronic infection by Trypanosoma cruzi . Revista Do Instituto De Medicina Tropical De São Paulo, 34(2), 177-180. https://www.revistas.usp.br/rimtsp/article/view/28913