Cardiac beta-receptors in experimental Chagas' disease
Keywords:
Chagas' disease, beta receptorsAbstract
Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase.Downloads
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Published
1995-02-01
Issue
Section
Trypanosomiasis
How to Cite
Enders, J. E., Paglini, P., Fernandez, A. R., Marco, F., & Palma, J. A. (1995). Cardiac beta-receptors in experimental Chagas’ disease . Revista Do Instituto De Medicina Tropical De São Paulo, 37(1), 59-63. https://www.revistas.usp.br/rimtsp/article/view/29231