Measles antibody prevalence after mass immunization campaign in Niterói, State of Rio de Janeiro, Brazil

Authors

  • Solange A Oliveira Universidade Federal Fluminense; Faculdade de Medicina; Departamento de Saúde da Comunidade; Disciplina de Doenças Infecciosas
  • Marilda M Siqueira Fundação Oswaldo Cruz; Departamento de Virologia and Bio-Manguinhos
  • George F Mann Fundação Oswaldo Cruz; Departamento de Virologia and Bio-Manguinhos
  • Antônio José L Costa Fundação Municipal de Saúde de Niterói
  • Maria Teresa C.N. Almeida Fundação Municipal de Saúde de Niterói
  • Mônica S Stavola Fundação Municipal de Saúde de Niterói
  • Hugo Tomasini Fundação Municipal de Saúde de Niterói
  • Jussara P Nascimento Fundação Oswaldo Cruz; Departamento de Virologia and Bio-Manguinhos

Keywords:

Measles, Vaccination, Seropidemiological survey

Abstract

Three months after a mass vaccination campaign (coverage: 100%) against measles a random seroepidemiological survey was carried out in students aged 1 to 19 years old in the Municipality of Niterói, State of Rio de Janeiro. Blood samples were tested for measles antibodies by enzyme immunosorbent assay (EIA) and negative cases were tested again using hemagglutination inhibition (HI) and plaque reduction neutralization (PRN). Of the 798 samples tested by EIA, 718 (90.2%) were positive for measles antibodies. PRN test was more sensitive than EIA and HI in detecting measles specific antibodies. The total antibody prevalence increased from 90.2% to 93.2% when HI was employed in EIA negative specimens and to 98.9% when PRN was used. After the mass vaccination campaign a marked decrease in measles incidence was observed in the municipality studied, showing the effectiveness of the strategy used for measles control in developing countries.

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Published

1996-10-01

Issue

Section

Soroepidemiology

How to Cite

Measles antibody prevalence after mass immunization campaign in Niterói, State of Rio de Janeiro, Brazil . (1996). Revista Do Instituto De Medicina Tropical De São Paulo, 38(5), 355-358. https://www.revistas.usp.br/rimtsp/article/view/29400