GB virus C/Hepatitis G virus and other putative hepatitis non A-E viruses


  • João Renato Rebello Pinho Instituto Adolfo Lutz; Serviço de Virologia
  • Luiz Caetano da Silva Universidade de São Paulo; Instituto de Medicina Tropical


hepatitis G, hepatitis F, GBV-C, HGV, HFV, non A-E hepatitis, HBV mutants


The identification of the major agents causing human hepatitis (Hepatitis A, B, C, D and E Viruses) was achieved during the last 30 years. These viruses are responsible for the vast majority of human viral hepatitis cases, but there are still some cases epidemiologically related to infectious agents without any evidence of infection with known virus, designated as hepatitis non A - E. Those cases are considered to be associated with at least three different viruses: 1 - Hepatitis B Virus mutants expressing its surface antigen (HBsAg) with altered epitopes or in low quantities; 2 - Another virus probably associated with enteral transmitted non A-E hepatitis, called Hepatitis F Virus. Still more studies are necessary to better characterize this agent; 3 - Hepatitis G Virus or GB virus C, recently identified throughout the world (including Brazil) as a Flavivirus responsible for about 10% of parenteral transmitted hepatitis non A-E. Probably still other unknown viruses are responsible for human hepatitis cases without evidence of infection by any of these viruses, that could be called as non A-G hepatitis.


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How to Cite

Pinho, J. R. R., & Silva, L. C. da. (1996). GB virus C/Hepatitis G virus and other putative hepatitis non A-E viruses . Revista Do Instituto De Medicina Tropical De São Paulo, 38(6), 441-450. Retrieved from



Invited review