Multiple brain abscesses due to Penicillium spp infection

Authors

  • Danilo Teixeira Noritomi University of São Paulo; Medical School; Hospital das Clínicas; Gastroenterology Department
  • Guilherme Linhares Bub University of São Paulo; Medical School; Hospital das Clínicas; Gastroenterology Department
  • Idal Beer University of São Paulo; Medical School; Hospital das Clínicas; Gastroenterology Department
  • Aloísio Souza Felipe da Silva University of São Paulo; Medical School; Hospital das Clínicas; Department of Pathology
  • Roberto de Cleva University of São Paulo; Medical School; Hospital das Clínicas; Gastroenterology Department
  • Joaquim José Gama-Rodrigues University of São Paulo; Medical School; Hospital das Clínicas; Gastroenterology Department

Keywords:

Penicilliosis, Penicillium spp, CNS infection, Fungal infection

Abstract

We present a case of central nervous system (CNS) infection by a member of the Penicillium genera in a HIV-negative man in Brazil. The patient was admitted complaining of loss of visual fields and speech disturbances. CT scan revealed multiple brain abscesses. Stereothacic biopsies revealed fungal infection and amphotericin B treatment begun with initial improvement. The patient died few days later as a consequence of massive gastrointestinal bleeding due to ruptured esophageal varices. The necropsy and final microbiologic analyses disclosed infection by Penicillium sp. There are thousands of fungal species of the Penicillium genera. Systemic penicilliosis is caused by the P. marneffei and was formerly a rare disease, but now is one of the most common opportunistic infection of AIDS patients in Southeast Asia. The clinical presentation usually involves the respiratory system and the skin, besides general symptoms like fever and weight loss. Penicillium spp infection caused by species other than P. marneffei normally cause only superficial or allergic disease but rare cases of invasive disease do occur. We report the fourth case of Penicillium spp CNS infection.

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Published

2005-06-01

How to Cite

Noritomi, D. T., Bub, G. L., Beer, I., Silva, A. S. F. da, Cleva, R. de, & Gama-Rodrigues, J. J. (2005). Multiple brain abscesses due to Penicillium spp infection . Revista Do Instituto De Medicina Tropical De São Paulo, 47(3), 167-170. Retrieved from https://www.revistas.usp.br/rimtsp/article/view/30912

Issue

Section

Case Report