Antifungal susceptibilities of clinical and environmental isolates of Cryptococcus neoformans in goiânia city, Goiás, Brasil

Authors

  • Lúcia Kioko Hasimoto Souza Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Orionalda de Fátima Lisboa Fernandes Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Cláudia Castelo Branco Artiaga Kobayashi Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Xisto Sena Passos Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Carolina Rodrigues Costa Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Janine Aquino Lemos Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia
  • Ary Henrique Souza-Júnior Universidade Católica de Goiás; Departamento de Biomedicina
  • Maria do Rosário Rodrigues Silva Universidade Federal de Goiás; Instituto de Patologia Tropical e Saúde Pública; Laboratório de Micologia

Keywords:

Cryptococcus neoformans, Antifungal agents, Cerebrospinal fluid, Environment

Abstract

We evaluated the antifungal activities of amphotericin B, fluconazole, itraconazole and voriconazole in 70 Cryptococcus neoformans strains obtained from cerebrospinal fluid from AIDS patients and 40 C. neoformans strains isolated from the environment. Four clinical isolates were identified as C. neoformans var. gattii. The susceptibility test was done using a broth microdilution method according to NCCLS M27-A2. Range minimal inhibitory concentrations (MICs) for C. neoformans clinical isolates were 0.06-1.0 µg/mL for amphotericin B, 0.125-8 µg/mL for fluconazole, 0.03-0.5 µg/mL for itraconazole and 0.03-0.25 µg/mL for voriconazole. C. neoformans environmental isolates showed range MICs 0.015-0.125 µg/mL, 0.25-2.0 µg/mL, 0.007-0.125 µg/mL and 0.03-0.25 µg/mL for amphotericin B, fluconazole, itraconazole and voriconazole respectively. The MICs results obtained from clinical and environmental isolates showed similar pattern of susceptibility and no resistance has been found in our isolates.

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Published

2005-10-01

Issue

Section

Mycology

How to Cite

Antifungal susceptibilities of clinical and environmental isolates of Cryptococcus neoformans in goiânia city, Goiás, Brasil . (2005). Revista Do Instituto De Medicina Tropical De São Paulo, 47(5), 253-256. https://www.revistas.usp.br/rimtsp/article/view/30934