Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report

Authors

  • Diego R.B. Pereira Universidade Estadual de Campinas; Instituto de Biologia; Laboratório de Química de Proteínas
  • Daniel Martins Universidade Estadual de Campinas; Instituto de Biologia; Laboratório de Química de Proteínas
  • Flavia V. Winck Universidade Estadual de Campinas; Instituto de Biologia; Laboratório de Química de Proteínas
  • Marcus B. Smolka Ludwig Institute of Cancer Research
  • Nancy F. Nishimura Centro de Diagnóstico de Doenças do Aparelho Digestivo; Laboratório de Bacteriologia
  • Elizabeth M.A. Rabelo-Gonçalves Centro de Diagnóstico de Doenças do Aparelho Digestivo; Laboratório de Bacteriologia
  • Natalicia H. Hara Centro de Diagnóstico de Doenças do Aparelho Digestivo; Laboratório de Bacteriologia
  • Sérgio Marangoni Universidade Estadual de Campinas; Instituto de Biologia; Laboratório de Química de Proteínas
  • José Murilo R. Zeitune Centro de Diagnóstico de Doenças do Aparelho Digestivo; Laboratório de Bacteriologia
  • José Camillo Novello Universidade Estadual de Campinas; Instituto de Biologia; Laboratório de Química de Proteínas

Keywords:

Helicobacter pylori, Proteome, Bidimensional electrophoresis, Chronic gastritis, Peptic ulcers

Abstract

Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patients with chronic gastritis and duodenal ulcers. A partial proteomic analysis of H. pylori strains was performed by bacterial lyses and proteins were separated by two-dimensional gel electrophoresis (2-DE). A comparative analysis was performed to verify a differential protein expression between these two 2-DE maps. These data should be useful to clarify the role of different proteins related to bacterial pathogenesis. This study will be completed using a larger number of samples and protein identification of H. pylori by MALDI-TOF mass spectrometry.

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Published

2006-06-01

Issue

Section

Preliminary Report

How to Cite

Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report . (2006). Revista Do Instituto De Medicina Tropical De São Paulo, 48(3), 175-177. https://www.revistas.usp.br/rimtsp/article/view/30999