COVID19: a variabilidade individual da resposta imunoinflamatória
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.180873Palavras-chave:
COVID-19, Síndrome respiratória aguda grave, Resposta imunoinflamatória, Modelo iceberg de doença, Resultado do tratamentoResumo
A diversidade das respostas imunoinflamatórias individuais humanas muito provavelmente tem papel na gravidade da doença Covid19 causada pela infecção pelo vírus SARS-CoV2. Marcadores imunológicos séricos durante a Covid19 podem guiar a escolha de terapias individualizadas com melhores resultados. O tratamento eficiente para Covid19 pode exigir: 1) detecção precoce da doença, 2) terapia medicamentosa combinada com alvo ao 3) ciclo de replicação do vírus e 4) terapia anti-inflamatória individualizada para perfis de respostas imunoinflamatórias humanas, administradas em tempo hábil. É improvável que a Covid19 seja a última doença humana emergente com potencial de alastramento veloz pandêmico. Reunir conhecimento sobre perfis de respostas imunoinflamatórias individuais dos hospedeiros humanos é uma oportunidade ímpar que pode nos levar a entender as diferenças dessas respostas entre indivíduos, abrindo caminho para estratégias terapêuticas mais rápidas e eficientes no combate à futuras epidemias.
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Copyright (c) 2022 Maria Goreti Rosa Freitas, Carolina Muruci-Cruz, Luiz Fernando Dale, Luis Eduardo da Cruz, Jorge Kalil
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
